Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation

被引：41

作者：

Yoshida, N

Yoshida, S ^{[1
]}

Araie, M

Handa, H

Nabeshima, Y

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Sakyo Ku, Kyoto 6068501, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Tokyo, Japan

[3] Tokyo Inst Technol, Fac Biosci & Biotechnol, Yokohama, Kanagawa 227, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 97卷 / 1-2期

关键词：

cornea; epithelium; ESE-1; differentiation; transcription factor; K12; keratin; K3; HCE cell;

D O I：

10.1016/S0925-4773(00)00419-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Involvement of an epithelium-specific transcription factor ESE-1/ESX/ELF3/jen (ESE-1) in corneal epithelial cell differentiation was investigated. ESE-1 was reported to be induced during terminal differentiation of the epidermis and primary keratinocytes and to transactivate target genes through ets binding sites. However, its expression and function in corneal epithelium have not been examined. We report here that ESE-1 is upregulated upon differentiation in mouse corneal epithelium and in immortalized human corneal epithelial cells (HCE). ESE-1 transactivates through the regulatory element of cornea-specific K12 keratin. Moreover, introduction of ESE-1 antisense RNA in HCE cells affect their differentiation. These data suggest the involvement of ESE-1 in differentiation of corneal epithelial cells. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：27 / 34

页数：8

共 27 条

[1] The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis [J].