Assessment of Oxidative Status of the Brain and Blood Plasma in Rats with Modeled Focal Cerebral Ischemia/Reperfusion Injury

被引：12

作者：

Devyatov, A. A. ^{[1
,2
]}

Fedorova, T. N. ^{[2
]}

Stvolinskii, S. L. ^{[2
]}

Belousova, M. A. ^{[3
]}

Medvedev, O. S. ^{[3
]}

Tutelyan, V. A. ^{[1
]}

机构：

[1] Fed Res Ctr Nutr & Biotechnol, Moscow, Russia

[2] Res Ctr Neurol, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 02期

关键词：

focal cerebral ischemia; oxidative stress; brain; blood plasma; ISCHEMIC-STROKE; STRESS;

D O I：

10.1007/s10517-017-3764-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Parameters of the oxidative status of the brain and blood plasma were measured in rats 24 h after 1-h focal cerebral ischemia. In the brain of rats exposed to cerebral ischemia, activities of superoxide dismutase and catalase were elevated. Ischemia reduced the total antioxidant activity of the brain and the levels of malonic dialdehyde and protein carbonyl derivatives. In the blood plasma of experimental rats, superoxide dismutase activity and malonic dialdehyde level increased and total antioxidant activity decreased, i.e. the shifts were similar to those in the brain. The ischemia-induced changes in the brain and blood were not always co-directed.

引用

页码：195 / 198

页数：4

共 15 条

[1]

Alexandrova Margarita L., 2007, P313, DOI 10.1016/B978-044452809-4/50156-3

[2] Oxidative stress and its role in the pathogenesis of ischaemic stroke [J].

Allen, C. L. ;

Bayraktutan, U. .

INTERNATIONAL JOURNAL OF STROKE, 2009, 4 (06) :461-470

[3]

Awooda HA, 2015, INT J HEALTH SCI-IJH, V9, P17

[4] α-lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats [J].

Deng, Houliang ;

Zuo, Xialin ;

Zhang, Jingjing ;

Liu, Xiaoxia ;

Liu, Li ;

Xu, Qian ;

Wu, Zhuomin ;

Ji, Aimin .

MOLECULAR MEDICINE REPORTS, 2015, 11 (05) :3659-3665

[5] Oxidative Stress After Thrombolysis-Induced Reperfusion in Human Stroke [J].

Dominguez, Carmen ;

Delgado, Pilar ;

Vilches, Angel ;

Martin-Gallan, Pilar ;

Ribo, Marc ;

Santamarina, Estevo ;

Molina, Carlos ;

Corbeto, Natalia ;

Rodriguez-Sureda, Victor ;

Rosell, Anna ;

Alvarez-Sabin, Jose ;

Montaner, Joan .

STROKE, 2010, 41 (04) :653-660

[6]

Fedorova TN, 1999, BIOCHEMISTRY-MOSCOW+, V64, P75

[7]

Kroemer G., 2013, CELL SENESCENCE METH

[8] Acute pathophysiological processes after ischaemic and traumatic brain injury [J].

Kunz, Alexander ;

Dirnagl, Ulrich ;

Mergenthaler, Philipp .

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY, 2010, 24 (04) :495-509

[9] Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury [J].

Manzanero, Silvia ;

Santro, Tomislav ;

Arumugam, Thiruma V. .

NEUROCHEMISTRY INTERNATIONAL, 2013, 62 (05) :712-718

[10] Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats [J].

McCann, Sarah K. ;

Dusting, Gregory J. ;

Roulston, Carli L. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (11) :2524-2534

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