Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain

被引：28
作者：
Machado-Vieira, R
Schmidt, AP
Avila, TT
Kapczinski, F
Soares, JC
Souza, DO
Portela, LVC
机构：
[1] Univ Fed Rio Grande do Sul, ICBS, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil
[2] Fdn Fac Fed Ciencias Med Porto Alegre, HMIPV, Mood Disorders Program, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Dept Psychiat, BR-90035003 Porto Alegre, RS, Brazil
[4] Univ Texas, Hlth Sci Ctr, Dept Psychiat, Div Mood & Anxiety Disorders, San Antonio, TX 78285 USA
来源：
LIFE SCIENCES | 2004年 / 76卷 / 07期
关键词：
bipolar disorder; ouabain; S100B protein; glial cells; mania;
D O I：
10.1016/j.lfs.2004.07.021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold increase in crossing responses in the open field test and increased 30% the cerebrospinal fluid concentration of S100B, as compared to vehicle group. Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：805 / 811
页数：7
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