A network-based method for identifying prognostic gene modules in lung squamous carcinoma

被引：11
作者：
Feng, Lin [1 ,2 ]
Tong, Run [3 ]
Liu, Xiaohong [4 ]
Zhang, Kaitai [1 ,2 ]
Wang, Guiqi [5 ]
Zhang, Lei [5 ]
An, Ning [1 ,2 ]
Cheng, Shujun [1 ,2 ]
机构：
[1] Peking Union Med Coll, Dept Etiol & Carcinogenesis, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
[2] Chinese Acad Med Sci, Canc Inst Hosp, Beijing 100730, Peoples R China
[3] China Japan Friendship Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China
[4] Maternal & Child Hlth Care Hosp Haidian, Dept Gynecol & Obstet, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Canc Hosp, Dept Endoscopy, Beijing 100730, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 14期
基金：
国家高技术研究发展计划(863计划);
关键词：
lung squamous carcinoma; multi-stage carcinogenesis; network-based; greedy searching; prognostic module; STEM-CELLS; CANCER; SURVIVAL; EXPRESSION; CARCINOGENESIS; MECHANISMS; TRANSITION; EVOLUTION; EMT; BAD;
D O I：
10.18632/oncotarget.7632
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Similarities in gene expression between both developing embryonic and precancerous tissues and cancer tissues may help identify much-needed biomarkers and therapeutic targets in lung squamous carcinoma. In this study, human lung samples representing ten successive time points, from embryonic development to carcinogenesis, were used to construct global gene expression profiles. Differentially expressed genes with similar expression in precancerous and cancer samples were identified. Using a network-based greedy searching algorithm to analyze the training cohort (n = 69) and three independent testing cohorts, we successfully identified a significant 22-gene module in which expression levels were correlated with overall survival in lung squamous carcinoma patients.
引用
收藏
页码：18006 / 18020
页数：15
相关论文
共 56 条
  • [21] Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance
    Hopewell, Emily L.
    Zhao, Weipeng
    Fulp, William J.
    Bronk, Crystina C.
    Lopez, Alexis S.
    Massengill, Michael
    Antonia, Scott
    Celis, Esteban
    Haura, Eric B.
    Enkemann, Steven A.
    Chen, Dung-Tsa
    Beg, Amer A.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (06) : 2509 - 2522
  • [22] Significance of Notch1-signaling Pathway in Human Pancreatic Development and Carcinogenesis
    Hu, Huankai
    Zhou, Lan
    Awadallah, Amad
    Xin, Wei
    [J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2013, 21 (03): : 242 - 247
  • [23] Overlapping gene expression in fetal mouse intestine development and human colorectal cancer
    Hu, M
    Shivdasani, RA
    [J]. CANCER RESEARCH, 2005, 65 (19) : 8715 - 8722
  • [24] Inflammation and cancer: An ancient link with novel potentials
    Hussain, S. Perwez
    Harris, Curtis C.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (11) : 2373 - 2380
  • [25] Ideker Trey, 2002, Bioinformatics, V18 Suppl 1, pS233
  • [26] Natural history of bronchial preinvasive lesions
    Ishizumi, Taichiro
    McWilliams, Annette
    MacAulay, Calum
    Gazdar, Adi
    Lam, Stephen
    [J]. CANCER AND METASTASIS REVIEWS, 2010, 29 (01) : 5 - 14
  • [27] Jeng K. S., 2015, CRIT REV ONCOL HEMAT
  • [28] Network-based survival-associated module biomarker and its crosstalk with cell death genes in ovarian cancer
    Jin, Nana
    Wu, Hao
    Miao, Zhengqiang
    Huang, Yan
    Hu, Yongfei
    Bi, Xiaoman
    Wu, Deng
    Qian, Kun
    Wang, Liqiang
    Wang, Changliang
    Wang, Hongwei
    Li, Kongning
    Li, Xia
    Wang, Dong
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [29] Jin NN, 2015, SCI REPORTS, V5
  • [30] Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Kaiser, Sergio
    Park, Young-Kyu
    Franklin, Jeffrey L.
    Halberg, Richard B.
    Yu, Ming
    Jessen, Walter J.
    Freudenberg, Johannes
    Chen, Xiaodi
    Haigis, Kevin
    Jegga, Anil G.
    Kong, Sue
    Sakthivel, Bhuvaneswari
    Xu, Huan
    Reichling, Timothy
    Azhar, Mohammad
    Boivin, Gregory P.
    Roberts, Reade B.
    Bissahoyo, Anika C.
    Gonzales, Fausto
    Bloom, Greg C.
    Eschrich, Steven
    Carter, Scott L.
    Aronow, Jeremy E.
    Kleimeyer, John
    Kleimeyer, Michael
    Ramaswamy, Vivek
    Settle, Stephen H.
    Boone, Braden
    Levy, Shawn
    Graff, Jonathan M.
    Doetschman, Thomas
    Groden, Joanna
    Dove, William F.
    Threadgill, David W.
    Yeatman, Timothy J.
    Coffey, Robert J., Jr.
    Aronow, Bruce J.
    [J]. GENOME BIOLOGY, 2007, 8 (07)
123456