Circulating IL-1β levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women

被引:55
作者
Qian, Nianfeng [1 ,2 ]
Chen, Xiaojun [2 ,4 ]
Han, Suping [2 ,3 ]
Qiang, Fulin [4 ]
Jin, Guangfu [1 ,2 ]
Zhou, Xiaoyi [1 ,2 ]
Dong, Jing [1 ,2 ]
Wang, Xinru [2 ]
Shen, Hongbing [1 ,2 ]
Hu, Zhibin [1 ,2 ]
机构
[1] Nanjing Med Univ, Ctr Canc, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R China
[2] Nanjing Med Univ, Lab Reprod Med, Nanjing 210029, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Gynecol, Nanjing 210029, Peoples R China
[4] Tumor Hosp Nantong City, Nantong 226000, Peoples R China
关键词
IL-1; beta; IL-1B; Polymorphism; Cervical cancer; Molecular epidemiology; INTERLEUKIN-1 RECEPTOR ANTAGONIST; GENE POLYMORPHISM; CYTOKINE; IL1RN-ASTERISK-2; DISEASE;
D O I
10.1007/s00432-009-0710-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long-term human papillomavirus (HPV) infection is a prerequisite for cervical cancer. IL-1 beta and IL-1Ra expression levels play an important role in cervical carcinogenesis. Several functional genetic variants in IL1B and IL-RN have been reported to be associated with IL-1 beta expression and cancer susceptibility. In the current study, we hypothesized that plasma IL-1 beta levels, IL-1B and IL-RN polymorphisms were candidate biomarkers for cervical cancer. We measured plasma IL-1 beta levels and genotyped IL-1B and IL-RN polymorphisms in a case-control study of 404 cervical cancer cases and 404 controls in Chinese women. The mean plasma IL-1 beta levels in cervical cancer cases (42.19 +/- A 31.55 pg/ml) was significantly higher than those in controls (34.86 +/- A 22.68 pg/ml, P = 0.0002), and plasma IL-1 beta levels above the 75% quartiles in controls (IL-1 beta a parts per thousand yen 46.94 pg/ml) were associated with a 1.74-fold significantly increased risk of cervical cancer [95% confidence interval (CI), 1.28-2.36], compared with those of lowest quartile. Multivariate logistic regression analyses revealed that the variant genotypes, IL-1B T-31C TC/CC and C-511T CT/TT, were associated with a significantly increased risk of cervical cancer [adjusted odds ratio (OR), 1.60; 95% CI, 1.16-2.21 for -31TC/CC, and adjusted OR, 1.52; 95% CI, 1.10-2.09 for -511CT/TT, respectively), especially among subjects having higher levels of IL-1 beta. However, IL-RN VNTR polymorphism was not associated with cervical cancer risk in the current study. Furthermore, the significant differences of IL-1 beta concentration between cervical cancer cases and controls were observed only among subjects carrying T-31C or C-511T variant genotypes. Functional IL-1B genotypes may modify plasma IL-1 beta concentrations to contribute to the etiology of cervical cancer in Chinese women; however, further perspective studies are warranted to test the causal effects of IL-1 beta concentration in cervical carcinogenesis.
引用
收藏
页码:709 / 716
页数:8
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