Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations

被引：122

作者：

Rodriguez-Novoa, Sonia ^{[1
]}

Labarga, Pablo ^{[1
]}

D'Avolio, Antonio ^{[2
]}

Barreiro, Pablo ^{[1
]}

Albalate, Marta ^{[3
]}

Vispo, Eugenia ^{[1
]}

Solera, Carmen ^{[1
]}

Siccardi, Marco ^{[2
]}

Bonora, Stefano ^{[2
]}

Di Perri, Giovanni ^{[2
]}

Soriano, Vincent ^{[1
]}

机构：

[1] Hosp Carlos III, Dept Infect Dis, Madrid, Spain

[2] Univ Turin, Infect Dis Serv, Turin, Italy

[3] Hosp Infanta Leonor, Dept Nephrol, Madrid, Spain

来源：

AIDS | 2010年 / 24卷 / 07期

关键词：

VIRUS-INFECTED PATIENTS; FANCONI-SYNDROME; RENAL-FAILURE; POPULATION PHARMACOKINETICS; DISOPROXIL FUMARATE; NEPHROTOXICITY; THERAPY; DYSFUNCTION; SAFETY; ADULTS;

D O I：

10.1097/QAD.0b013e32833202e2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tenofovir (TFV) is a nucleotide analogue active against HIV and hepatitis B virus. Although TFV rarely affects the glomerular function, abnormalities in the kidney tubular function appear to be quite common. The relationship between TFV exposure and kidney tubular dysfunction (KTD) was examined prospectively in 92 HIV-infected individuals. Median TFV plasma trough concentration was higher in patients with KTD than in the rest (182 vs. 106 ng/ml; P=0.001). This dose-dependent effect further supports an involvement of TFV in KTD.

引用

收藏

页码：1064 / 1066

页数：3

相关论文

共 18 条

[1] Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study [J].

Anderson, Peter L. ;

Lamba, Jatinder ;

Aquilante, Christina L. ;

Schuetz, Erin ;

Fletcher, Courtney V. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 42 (04) :441-449

[2] Phase I/II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults [J].

Barditch-Crovo, P ;

Deeks, SG ;

Collier, A ;

Safrin, S ;

Coakley, DF ;

Miller, M ;

Kearney, BP ;

Coleman, RL ;

Lamy, PD ;

Kahn, JO ;

McGowan, I ;

Lietman, PS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (10) :2733-2739

[3] Tenofovir-related nephrotoxicity in HIV-infected patients [J].

Barrios, A ;

García-Benayas, T ;

González-Lahoz, J ;

Soriano, V .

AIDS, 2004, 18 (06) :960-963

[4] Rapid communication: Acute renal failure associated with tenofovir: Evidence of drug-induced nephrotoxicity [J].

Coca, S ;

Perazella, MA .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 324 (06) :342-344

[5] A new assay based on solid-phase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients [J].

D'Avolio, Antonio ;

Sciandra, Mauro ;

Siccardi, Marco ;

Baietto, Lorena ;

de Requena, Daniel Gonzalez ;

Bonora, Stefano ;

Di Perri, Giovanni .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2008, 46 (06) :524-528

[6] Population Pharmacokinetics of Tenofovir in AIDS Patients [J].

Gagnieu, Marie-Claude ;

El Barkil, Mirna ;

Livrozet, Jean-Michel ;

Cotte, Laurent ;

Miailhes, Patrick ;

Boibieux, Andre ;

Guitton, Jerome ;

Tod, Michel .

JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 48 (11) :1282-1288

[7] Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy [J].

Izzedine, Hassane ;

Hulot, Jean-Sebastien ;

Villard, Eric ;

Goyenvalle, Catherine ;

Dominguez, Stephanie ;

Ghosn, Jade ;

Valantin, Marc Antoine ;

Lechat, Philippe ;

Deray, Gilbert .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (11) :1481-1491

[8] Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy [J].

Jullien, V ;

Tréluyer, JM ;

Rey, E ;

Jaffray, P ;

Krivine, A ;

Moachon, L ;

Lillo-Le Louet, A ;

Lescoat, A ;

Dupin, N ;

Salmon, D ;

Pons, G ;

Urien, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) :3361-3366

[9] Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: Three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus [J].

Karras, A ;

Lafaurie, M ;

Furco, A ;

Bourgarit, A ;

Droz, D ;

Sereni, D ;

Legendre, C ;

Martinez, F ;

Molina, JM .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (08) :1070-1073

[10] Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir [J].

Labarga, Pablo ;

Barreiro, Pablo ;

Martin-Carbonero, Luz ;

Rodriguez-Novoa, Sonia ;

Solera, Carmen ;

Medrano, Jose ;

Rivas, Pablo ;

Albalater, Marta ;

Blanco, Francisco ;

Moreno, Victoria ;

Vispo, Eugenia ;

Soriano, Vincent .

AIDS, 2009, 23 (06) :689-696