Plants from the genus Eugenia as promising therapeutic agents for the management of diabetes mellitus: A review

被引：32

作者：

Araujo, Nayara Macedo Peixoto ^{[1
]}

Arruda, Henrique Silvano ^{[1
,2
]}

Farias, David de Paulo ^{[1
]}

Molina, Gustavo ^{[3
]}

Pereira, Gustavo Araujo ^{[4
]}

Pastore, Glaucia Maria ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80,POB 13083-862, BR-13083862 Campinas, SP, Brazil

[2] Univ Campinas UNICAMP, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, BR-13083862 Campinas, SP, Brazil

[3] Univ Fed Vales Jequitinhonha & Mucuri, Inst Sci & Technol, Food Engn, BR-39100000 Diamantina, MG, Brazil

[4] Fed Univ Para UFPA, Inst Technol, Sch Food Engn, BR-66075110 Belem, Para, Brazil

来源：

FOOD RESEARCH INTERNATIONAL | 2021年 / 142卷

基金：

巴西圣保罗研究基金会;

关键词：

Eugenia species; -amylase; -glucosidase; Oxidative stress; Insulin resistance; Advanced glycation end-products; Insulin secretion; Pancreatic ?-cells; STIMULATED INSULIN-SECRETION; SKELETAL-MUSCLE CELLS; PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITY; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; DIETARY POLYPHENOLS; INHIBITORY-ACTIVITY; BIOACTIVE COMPOUNDS; PROTEIN GLYCATION;

D O I：

10.1016/j.foodres.2021.110182

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This review combined scientific data regarding the use of genus Eugenia plants for the management of diabetes. Diabetes mellitus is a chronic metabolic disease mainly characterized by hyperglycaemia, which can lead to serious health complications. Scientists have been seeking therapeutic compounds in plants, reporting the species of the genus Eugenia as a potential source of phytochemicals with antidiabetic properties. In vitro and in vivo studies have proved that the bioactive compounds in the genus Eugenia can positively affect the biomarkers of diabetes. We discussed the phytochemical profile of the genus Eugenia and its mechanism of action on diabetes, which could modulate carbohydrate metabolism, glucose homeostasis, and insulin secretion, inhibit carbohy-drases and reduce oxidative stress, suppressing the formation of advanced glycation end-products and protect-ing/regenerating pancreatic beta-cells. Therefore, plants of the genus Eugenia showed therapeutic potential to be used in the treatment of diabetes and its comorbidities.

引用

页数：16

共 132 条

[1]

Adebajo A. C., 2013, PLANTA MED, V79, DOI [10.1055/s-0033-1352021, DOI 10.1055/S-0033-1352021]

[2] Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes [J].

Aguayo-Mazzucato, Cristina ;

Bonner-Weir, Susan .

CELL METABOLISM, 2018, 27 (01) :57-67

[3] α-amylase inhibitory activity of some Malaysian plants used to treat diabetes;: with particular reference to Phyllanthus amarus [J].

Ali, Hasenah ;

Houghton, P. J. ;

Soumyanath, Amala .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 107 (03) :449-455

[4]

[Anonymous], J SUPERCRIT FLUID, V86, P4, DOI [10.1016/j.supflu.2013.11.014, DOI 10.1016/J.SUPFLU.2013.11.014]

[5] Improving effects of the extracts from Eugenia uniflora on hyperglycemia and hypertriglyceridemia in mice [J].

Arai, I ;

Amagaya, S ;

Komatsu, Y ;

Okada, M ;

Hayashi, T ;

Kasai, M ;

Arisawa, M ;

Momose, Y .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 68 (1-3) :307-314

[6]

ARMBRUSTER DA, 1987, CLIN CHEM, V33, P2153

[7] Araticum (Annona crassiflora Mart.) as a source of nutrients and bioactive compounds for food and non-food purposes: A comprehensive review [J].

Arruda, Henrique Silvano ;

Pastore, Glaucia Maria .

FOOD RESEARCH INTERNATIONAL, 2019, 123 :450-480

[8] ANTI-DIABETIC POTENTIAL OF PHENOLIC COMPOUNDS: A REVIEW [J].

Asgar, Md Ali .

INTERNATIONAL JOURNAL OF FOOD PROPERTIES, 2013, 16 (01) :91-103

[9] Dietary polyphenols as potential nutraceuticals in management of diabetes: A review [J].

Bahadoran Z. ;

Mirmiran P. ;

Azizi F. .

Journal of Diabetes & Metabolic Disorders, 12 (1)

[10] Phytochemical composition, antioxidant and in vivo antidiabetic activities of the hydroethanolic extract of Eugenia florida DC. (Myrtaceae) leaves [J].

Bastos, R. G. ;

Salles, B. C. C. ;

Bini, I. F. ;

Castaldini, L. P. ;

Silva, L. C. D. ;

Vilela, A. A. ;

Micheloni, A. L. C. ;

da Silva, G. M. ;

da Silva, P. H. C. ;

Maure, A. K. ;

Santos, L. L. ;

Rosa, C. P. ;

da Silva Amorim, A. F. ;

da Rocha, C. Q. ;

Vilegas, W. ;

de Araujo Paula, F. B. ;

da Silva, G. A. ;

da Silva, M. A. .

SOUTH AFRICAN JOURNAL OF BOTANY, 2019, 123 :317-332

← 1 2 3 4 5 6 7 8 9 10 →