Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

被引：1

作者：

Ricci, Jeremy ^{[1
]}

Min, Dongguk ^{[1
]}

Oh, Miyeon ^{[1
]}

Lim, Hyenchong ^{[1
]}

Chung, Won-Yoon ^{[2
]}

Park, Kwang-Kyun ^{[2
]}

Jung, Mankil ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

[2] Yonsei Univ, Dept Oral Biol, Coll Dent, Seoul 120752, South Korea

来源：

MEDICINAL CHEMISTRY | 2015年 / 11卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Daumone; glycolipid; antiangiogenic activity; synthesis; CAENORHABDITIS-ELEGANS; ANTICANCER ACTIVITY; GLYCOLIPID HYBRIDS; LARVAL DEVELOPMENT; PHEROMONE;

D O I：

10.2174/1573406411666150514100630

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

引用

页码：747 / 752

页数：6

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