Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release

被引：20

作者：

Chen, Changhui ^{[1
]}

Chen, Yong ^{[1
]}

Dai, Xianyin ^{[1
]}

Li, Jingjing ^{[1
]}

Jia, Shanshan ^{[1
]}

Wang, Shuaipeng ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 22期

关键词：

MOLECULAR RECOGNITION; MULTIDRUG-RESISTANCE; CANCER; DELIVERY; PRODRUG;

D O I：

10.1039/d1cc00292a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hyaluronidase-responsive polysaccharide supramolecular assembly was constructed from an amphiphilic beta-cyclodextrin bearing seven hexylimidazolium units (AMCD), adamantyl-grafted hyaluronic acid, and chlorambucil, which showed specific cancer cell targeting and controlled drug release abilities. Interestingly, ternary supramolecular assembly can disassemble in the presence of hyaluronidase, and the released AMCD can assemble with ATP to form a stable 1 : 1 complex, which enhanced the efficacy of chlorambucil on cancer chemotherapy by inhibiting ATP hydrolysis.

引用

页码：2812 / 2815

页数：4

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