Effects of unsaturated free fatty acids on adhesion and on gene expression of extracellular matrix macromolecules in human osteoblast-like cell cultures

被引：20

作者：

Musacchio, Estella ^{[1
]}

Priante, Giovanna ^{[1
]}

Budakovic, Alessandro ^{[1
]}

Baggio, Bruno ^{[1
]}

机构：

[1] Univ Padua, Dept Med & Surg Sci, Padua, Italy

来源：

CONNECTIVE TISSUE RESEARCH | 2007年 / 48卷 / 01期

关键词：

bone metabolism; cell adhesion; extracellular matrix; fatty acids; osteoblasts;

D O I：

10.1080/03008200601056528

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To investigate the possible role for unsaturated free fatty acids in osteoblast adhesion, the effects of two polyunsaturated fatty acids (PUFAs), arachidonic (AA) and eicosapentaenoic (EPA) acids, and of one monounsaturated fatty acid, oleic acid (OA), on adhesion to the substrate and on gene expression of three extracellular matrix macromolecules were investigated in an in vitro model system-cultured osteoblast-like human cells. AA, but neither EPA nor OA, diminished bone cell adhesion, whereas both EPA and OA, but not AA, increased gene expression of type I collagen and fibronectin via a transforming growth factor-beta-independent mechanism. These results extend previous evidence for unsaturated fatty acids in bone cell metabolism.

引用

页码：34 / 38

页数：5

共 25 条

[1] Anchorage-dependent cell cycle progression [J].