Prognostic significance of TRIM59 for cancer patient survival A systematic review and meta-analysis

被引：9

作者：

Wang, Min ^{[1
]}

Chao, Ce ^{[1
]}

Luo, Guanghua ^{[2
]}

Wang, Bin ^{[1
]}

Zhan, Xianghong ^{[1
]}

Di, Dongmei ^{[1
]}

Qian, Yongxiang ^{[1
]}

Zhang, Xiaoying ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Cardiothorac Surg, 185 Juqian St, Changzhou 213003, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 3, Comprehens Lab, Changzhou, Jiangsu, Peoples R China

来源：

MEDICINE | 2019年 / 98卷 / 48期

关键词：

cancer; carcinoma; meta-analysis; prognosis; TRIM59; tumor; TO-MESENCHYMAL TRANSITION; SIGNALING PATHWAY; INDUCED AUTOPHAGY; PROTEINS; GENE;

D O I：

10.1097/MD.0000000000018024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The family of tripartite motif (TRIM) proteins, which includes 80 known TRIM protein genes in humans, play a key role in cellular processes. TRIM59, a member of the TRIM family of proteins, has been reported to be involved in the carcinogenesis of multiple types of tumors. However, the prognostic value of TRIM59 in the survival of tumor patients remains controversial. We therefore conducted a meta-analysis to assess the prognostic significance of TRIM59 in cancer patients. Materials and methods: PubMed, Embase, VIP, CNKI and Wanfang Data were searched for eligible reports published before September 30, 2018. The hazard ratio (HR) and 95% confidence intervals (CIs) were adopted to estimate the association between TRIM59 and overall survival (OS). Results: Six studies with 1584 patients were included to assess the effect. The results showed that high levels of TRIM59 were significantly associated with poor OS in cancer patients (HR = 1.43, 95%CI: 1.24-1.66, P < .001), indicating that higher TRIM59 expression could be an independent prognostic factor for poor survival in cancer patients. Conclusion: Our meta-analysis suggests that higher TRIM59 expression predicts poor prognosis in cancer patients, and it may therefore serve as a promising prognostic factor.

引用

页数：7

共 24 条

[11] TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation [J].