Positioning Europe for the EPITRANSCRIPTOMICS challenge

被引：17

作者：

Jantsch, Michael F. ^{[1
]}

Quattrone, Alessandro ^{[2
]}

O'Connell, Mary ^{[3
]}

Helm, Mark ^{[4
]}

Frye, Michaela ^{[5
]}

Macias-Gonzales, Manuel ^{[6
]}

Ohman, Marie ^{[7
]}

Ameres, Stefan ^{[8
]}

Willems, Luc ^{[9
]}

Fuks, Francois ^{[10
]}

Oulas, Anastasis ^{[11
]}

Vanacova, Stepanka ^{[3
]}

Nielsen, Henrik ^{[12
]}

Bousquet-Antonelli, Cecile ^{[13
]}

Motorin, Yuri ^{[14
]}

Roignant, Jean-Yves ^{[15
]}

Balatsos, Nikolaos ^{[16
]}

Dinnyes, Andras ^{[17
]}

Baranov, Pavel ^{[18
]}

Kelly, Vincent ^{[19
]}

Lamm, Ayelet ^{[20
]}

Rechavi, Gideon ^{[21
]}

Pelizzola, Mattia ^{[22
]}

Liepins, Janis ^{[23
]}

Kholodnyuk, Irina Holodnuka ^{[24
]}

Zammit, Vanessa ^{[25
]}

Ayers, Duncan ^{[26
]}

Drablos, Finn ^{[27
]}

Dahl, John Arne ^{[28
]}

Bujnicki, Janusz ^{[29
]}

Jeronimo, Carmen ^{[30
]}

Almeida, Raquel ^{[31
]}

Neagu, Monica ^{[32
]}

Costache, Marieta ^{[33
]}

Bankovic, Jasna ^{[34
]}

Banovic, Bojana ^{[35
]}

Kyselovic, Jan ^{[36
]}

Valor, Luis Miguel ^{[37
]}

Selbert, Stefan ^{[38
]}

Pir, Pinar ^{[37
]}

Demircan, Turan ^{[38
]}

Cowling, Victoria ^{[39
]}

Schaefer, Matthias ^{[1
]}

Rossmanith, Walter ^{[1
]}

Lafontaine, Denis ^{[40
]}

David, Alexandre ^{[41
]}

Carre, Clement ^{[42
]}

Lyko, Frank ^{[43
]}

Schaffrath, Raffael ^{[44
]}

Schwartz, Schraga ^{[45
]}

机构：

[1] Med Univ Vienna, Dept Cell & Dev Biol, Vienna, Austria

[2] Univ Trento, Trento, Italy

[3] Masaryk Univ, CEITEC, Brno, Czech Republic

[4] Johannes Gutenberg Univ Mainz, Mainz, Germany

[5] Univ Cambridge, Cambridge, England

[6] Hosp Complex Malaga Virgen de la Victoria, Malaga, Spain

[7] Stockholm Univ, Stockholm, Sweden

[8] IMBA Inst Mol Biotechnol, Vienna, Austria

[9] Univ Liege, Mol & Cellular Epigenet, Interdisciplinary Cluster Appl Genoprote GIGA, Sart Tilman Par Liege, Belgium

[10] ULB, Fac Med, Brussels, Belgium

[11] CING, Engomi, Cyprus

[12] Univ Copenhagen, Copenhagen, Denmark

[13] Univ Perpignan, CNRS, Perpignan, France

[14] Lorraine Univ, CNRS, Biopole UL, Lorraine, France

[15] Inst Mol Biol, Mainz, Germany

[16] Univ Thessaly, Dept Biochem & Biotechnol Thessaly, Volos, Greece

[17] Biotalentum Ltd Godollo, Godollo, Hungary

[18] Univ Coll Cork, Dept Biochem, Cork, Ireland

[19] Trinity Coll Dublin, Trinity Biomed Sci Inst, Dublin, Ireland

[20] Technion Israel Inst Technol, Haifa, Israel

[21] Tel Aviv Univ, Tel Aviv, Israel

[22] Ctr Genom Sci IIT SEMM, Milan, Italy

[23] Univ Latvia, Riga, Latvia

[24] Riga Stradins Univ, Kirhensteins Inst Microbiol, Riga, Latvia

[25] St Lukes Hosp, Natl Blood Transfus Serv, Pieta, Malta

[26] Univ Malta, Ctr Mol Med & Biobanking Biomed Sci, Msida, Malta

[27] Norwegian Univ Sci & Technol, Fac Med Norwegian, Dept Canc Res & Mol Med, Trondheim, Norway

[28] Oslo Univ Hosp, Oslo, Norway

[29] Int Inst Mol & Cell Biol Warsaw, Warsaw, Poland

[30] Inst Portugues Oncol Porto, Porto, Portugal

[31] IPATIMUP, Porto, Portugal

[32] Victor Babes Natl Inst Pathol Bucharest, Bucharest, Romania

[33] Univ Bucharest, Fac Biol, Bucharest, Romania

[34] Inst Biol Res Dr Sinisa Stankovic, Belgrade, Serbia

[35] Univ Belgrade, Inst Mol Genet & Genet Engn, Belgrade, Serbia

[36] Univ Bratislava, Fac Pharm, Bratislava, Slovakia

[37] Gebze Tech Univ, Gebze, Turkey

[38] Istanbul Medipol Univ, Istanbul, Turkey

[39] Univ Dundee, Ctr Gene Regulat & Express, Sch Life Sci, Dundee, Scotland

[40] Univ Libre Bruxelles, Gosselies, Belgium

[41] Inst Genom Fonct, Montpellier, France

[42] Pierre & Marie Curie Univ, Inst Biol Paris Seine, Inst Biol Paris, Paris, France

[43] German Canc Res Ctr, Heidelberg, Germany

[44] Univ Kassel, Kassel, Germany

[45] Weizmann Inst Sci, Rehovot, Israel

[46] Inst Adv Biosci, Grenoble, France

[47] Fdn IMDEA Alimentac, Ctra Canto Blanco, Madrid, Spain

[48] Germans Trias & Pujol Res Inst, Barcelona, Spain

[49] Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh, Midlothian, Scotland

[50] Francis Crick Inst, London, England

来源：

RNA BIOLOGY | 2018年 / 15卷 / 06期

基金：

奥地利科学基金会;

关键词：

database of Modification; detection of RNA modification; epitranscriptomics; European funding; model systems;

D O I：

10.1080/15476286.2018.1460996

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the similar to 150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

引用

页码：829 / 831

页数：3