Protein-based ferrogels

被引：4

作者：

Mody, Puja ^{[1
]}

Hart, Cassidy ^{[1
]}

Romano, Siena ^{[1
]}

El-Magbri, Mariam ^{[1
]}

Esson, Moira M. ^{[1
]}

Ibeh, Trisha ^{[1
]}

Knowlton, Elizabeth D. ^{[2
]}

Zhang, Ming ^{[3
]}

Wagner, Michael J. ^{[3
]}

Hartings, Matthew R. ^{[1
]}

机构：

[1] Amer Univ, Dept Chem, 4400 Massachusetts Ave NW, Washington, DC 20016 USA

[2] NIST, Gaithersburg, MD 20899 USA

[3] George Washington Univ, Dept Chem, Washington, DC 20052 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 159卷

关键词：

Polymer microgel; Protein microgel; Hydrogel; Magnetic nanoparticle; MAGNETIC NANOPARTICLES; CONTROLLED-RELEASE; DRUG-DELIVERY; MICROSPHERES; HYDROGELS; AGGREGATION; FERRITIN; FE3O4;

D O I：

10.1016/j.jinorgbio.2016.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a novel synthesis in which hemoglobin and Fe2+ react, in the presence of KNO3 and KOH, to produce protein microgels that contain magnetic iron oxide nanoparticles. The synthesis results in microgels with polymer properties (denaturing and glass transition temperatures) that are consistent with the dried protein. The iron oxide nanoparticles that exhibit an average diameter of 22 nm, are ferrimagnetic, and display properties consistent with Fe3O4. The multiple functional capabilities displayed by these materials: biocompatibility, magnetism, dye uptake and controlled release, and other properties archetypal of hydrogels, will make the magnetic hydrogels attractive for a number of biomedical applications. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：7 / 13

页数：7

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