Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

被引：88

作者：

Pazukhina, Ekaterina ^{[1
,2
]}

Andreeva, Margarita ^{[3
]}

Spiridonova, Ekaterina ^{[3
]}

Bobkova, Polina ^{[3
]}

Shikhaleva, Anastasia ^{[3
]}

El-Taravi, Yasmin ^{[3
]}

Rumyantsev, Mikhail ^{[3
]}

Gamirova, Aysylu ^{[3
]}

Bairashevskaia, Anastasiia ^{[3
]}

Petrova, Polina ^{[3
]}

Baimukhambetova, Dina ^{[3
]}

Pikuza, Maria ^{[3
]}

Abdeeva, Elina ^{[3
]}

Filippova, Yulia ^{[3
]}

Deunezhewa, Salima ^{[3
]}

Nekliudov, Nikita ^{[3
]}

Bugaeva, Polina ^{[3
]}

Bulanov, Nikolay ^{[4
]}

Avdeev, Sergey ^{[5
]}

Kapustina, Valentina ^{[6
]}

Guekht, Alla ^{[7
,8
]}

DunnGalvin, Audrey ^{[3
,9
]}

Comberiati, Pasquale ^{[10
]}

Peroni, Diego G. ^{[10
]}

Apfelbacher, Christian ^{[11
]}

Genuneit, Jon ^{[12
]}

Reyes, Luis Felipe ^{[13
,14
]}

Brackel, Caroline L. H. ^{[15
,16
]}

Fomin, Victor ^{[17
]}

Svistunov, Andrey A. ^{[17
]}

Timashev, Peter ^{[18
]}

Mazankova, Lyudmila ^{[19
]}

Miroshina, Alexandra ^{[20
]}

Samitova, Elmira ^{[19
,20
]}

Borzakova, Svetlana ^{[8
,21
]}

Bondarenko, Elena ^{[3
]}

Korsunskiy, Anatoliy A. ^{[3
]}

Carson, Gail ^{[22
]}

Sigfrid, Louise ^{[22
]}

Scott, Janet T. ^{[23
]}

Greenhawt, Matthew ^{[24
]}

Buonsenso, Danilo ^{[25
,26
,27
]}

Semple, Malcolm G. ^{[28
,29
]}

Warner, John O. ^{[30
]}

Olliaro, Piero ^{[22
]}

Needham, Dale M. ^{[31
,32
,33
]}

Glybochko, Petr ^{[17
]}

Butnaru, Denis ^{[17
]}

Osmanov, Ismail M. ^{[8
,20
]}

Munblit, Daniel ^{[3
,7
,30
]}

机构：

[1] Russian Presidential Acad Natl Econom Publ Adm, Inst Appl Econ Studies, Lab Hlth Econ, Moscow, Russia

[2] Financial Res Inst Minist Finance Russian Federat, Ctr Adv Financial Planning, Macroecon Anal & Financial Stat, Moscow, Russia

[3] Sechenov Univ, Sechenov First Moscow State Med Univ, Inst Childs Hlth, Dept Paediat & Paediat Infect Dis, Moscow, Russia

[4] Sechenov Univ, Sechenov First Moscow State Med Univ, Tareev Clin Internal Dis, Moscow, Russia

[5] Sechenov Univ, Sechenov First Moscow State Med Univ, Clin Pulmonol, Moscow, Russia

[6] Sechenov Univ, Sechenov First Moscow State Med Univ, Inst Clin Med, Dept Internal Med, Moscow, Russia

[7] Res & Clin Ctr Neuropsychiat, Moscow, Russia

[8] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[9] Univ Coll Cork, Sch Appl Psychol, Cork City, Cork, Ireland

[10] Univ Pisa, Dept Clin & Expt Med, Sect Pediat, Pisa, Italy

[11] Otto Guericke Univ Magdeburg, Inst Social Med & Hlth Syst Res, Fac Med, Magdeburg, Germany

[12] Univ Leipzig, Med Fac, Dept Pediat, Pediat Epidmiol, Leipzig, Germany

[13] Univ La Sabana, Chia, Colombia

[14] Clin Univ Sabana, Chia, Colombia

[15] Univ Amsterdam, Emma Childrens Hosp, Dept Pediat Pulmonol, Med Ctr, Amsterdam, Netherlands

[16] Tergooi MC, Dept Pediat, Hilversum, Netherlands

[17] Sechenov Univ, Sechenov First Moscow State Med Univ, Moscow, Russia

[18] Sechenov Univ, Sechenov First Moscow State Med Univ, Inst Regenerat Med, Moscow, Russia

[19] Russian Med Acad, Continuous Profess Educ, Minist Healthcare Russian Federat, Moscow, Russia

[20] ZA Bashlyaeva Childrens Municipal Clin Hosp, Moscow, Russia

[21] Res Inst Healthcare Org & Med Management, Moscow Healthcare Dept, Moscow, Russia

[22] Univ Oxford, ISARIC Global Support Ctr, Nuffield Dept Med, Oxford, England

[23] Univ Glasgow Ctr Virus Res, MRC, Glasgow, Scotland

[24] Univ Colorado, Dept Pediat Sect Allergy Immunol, Childrens Hosp Colorado, Sch Med, Aurora, CO USA

[25] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy

[26] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base, Clin Intensivol & Perioperatorie, Rome, Italy

[27] Univ Cattolica Sacro Cuore, Ctr Global Hlth Res & Studies, Rome, Italy

[28] Univ Liverpool, Hlth Protect Res Unit Emerging & Zoonot Infect, Inst Infect Vet & Ecol Sci, Fac Hlth & Life Sci, Liverpool, England

[29] Alder Hey Childrens Hosp, Dept Resp Med, Liverpool, England

[30] Imperial Coll London, Inflammat Repair & Dev Sect, Natl Heart & Lung Inst, Fac Med, London, England

[31] Johns Hopkins Univ, Outcomes Crit Illness & Surg, OACIS, Res Grp, Baltimore, MD USA

[32] Johns Hopkins Univ, Dept Med Pulm & Crit Care Med, Sch Med, Baltimore, MD USA

[33] Johns Hopkins Univ, Phys Med & Rehabil, Sch Med, Baltimore, MD USA

来源：

BMC MEDICINE | 2022年 / 20卷 / 01期

关键词：

Adults; Children; COVID-19; sequelae; Long COVID; Post-acute sequelae of SARS-CoV-2 infection; PASC; Post-COVID-19; condition; Prevalence; Risk factor; COVID-19; CONSEQUENCES;

D O I：

10.1186/s12916-022-02448-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47-53) in adults and 20% (95% CI 16-24) in children at 6 months, with decline to 34% (95% CI 31-37) and 11% (95% CI 8-14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.

引用

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