Allergens with Protease Activity from House Dust Mites

被引：79

作者：

Reithofer, Manuel ^{[1
]}

Jahn-Schmid, Beatrice ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Pathophysiol & Allergy Res, A-1090 Vienna, Austria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 07期

基金：

奥地利科学基金会;

关键词：

house dust mite; allergen; protease; Der p 1; DERMATOPHAGOIDES-PTERONYSSINUS; EPITHELIAL-CELLS; DENDRITIC CELLS; BRONCHIAL EPITHELIUM; PROTEOLYTIC ACTIVITY; CYSTEINE PROTEASES; AIRWAY EPITHELIUM; TIGHT JUNCTIONS; FECAL PELLETS; P;

D O I：

10.3390/ijms18071368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Globally, house dust mites (HDM) are one of the main sources of allergens causing Type I allergy, which has a high risk of progressing into a severe disabling disease manifestation such as allergic asthma. The strong protease activities of a number of these allergens are thought to be involved in several steps of the pathophysiology of this allergic disease. It has been a common notion that protease activity may be one of the properties that confers allergenicity to proteins. In this review we summarize and discuss the roles of the different HDM proteases in the development of Type I allergy.

引用

页数：9

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