NAFLD and Atherosclerosis: Two Sides of the Same Dysmetabolic Coin?

被引：98

作者：

Stols-Goncalves, Daniela ^{[1
]}

Hovingh, G. Kees ^{[1
]}

Nieuwdorp, Max ^{[1
]}

Holleboom, Adriaan G. ^{[1
]}

机构：

[1] Univ Amsterdam, Med Ctr, Dept Vasc Med, Amsterdam, Netherlands

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 12期

关键词：

FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; NONALCOHOLIC STEATOHEPATITIS; SUBCLINICAL ATHEROSCLEROSIS; CONFERS SUSCEPTIBILITY; WIDE ASSOCIATION; SLEEP-APNEA; FIBROSIS; TM6SF2; PNPLA3;

D O I：

10.1016/j.tem.2019.08.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of non-alcoholic fatty liver disease (NAFLD) is strongly increasing and may put patients at increased risk for atherosclerotic cardiovascular disease (asCVD). Both disease phenotypes often co-occur, in the case of obesity, insulin resistance, diabetes mellitus type 2, and the metabolic syndrome. We explore the pathogenesis of NAFLD, the epidemiology of asCVD in NAFLD patients, shared drivers of both phenotypes, and factors caused by NAFLD that contribute to asCVD. Genetic studies support that NAFLD may drive asCVD through mixed hyperlipidemia. Next, we discuss the prospects of lifestyle improvement and pharmacological treatment of NAFLD for asCVD risk reduction. Finally, we point out that earlier identification of patients with NAFLD should be pursued by increasing awareness of the association of these two phenotypes and collaboration between the involved physiclans.

引用

页码：891 / 902

页数：12

共 71 条

[1] Derivation and validation of a cardiovascular risk score for prediction of major acute cardiovascular events in non-alcoholic fatty liver disease; the importance of an elevated mean platelet volume [J].

Abeles, Robin D. ;

Mullish, Benjamin H. ;

Forlano, Roberta ;

Kimhofer, Torben ;

Adler, Maciej ;

Tzallas, Alexandros ;

Giannakeas, Nikolaos ;

Yee, Michael ;

Mayet, Jamil ;

Goldin, Robert D. ;

Thursz, Mark R. ;

Manousou, Pinelopi .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 49 (08) :1077-1085

[2] A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease [J].

Abul-Husn, N. S. ;

Cheng, X. ;

Li, A. H. ;

Xin, Y. ;

Schurmann, C. ;

Stevis, P. ;

Liu, Y. ;

Kozlitina, J. ;

Stender, S. ;

Wood, G. C. ;

Stepanchick, A. N. ;

Still, M. D. ;

McCarthy, S. ;

O'Dushlaine, C. ;

Packer, J. S. ;

Balasubramanian, S. ;

Gosalia, N. ;

Esopi, D. ;

Kim, S. Y. ;

Mukherjee, S. ;

Lopez, A. E. ;

Fuller, E. D. ;

Penn, J. ;

Chu, X. ;

Luo, J. Z. ;

Mirshahi, U. L. ;

Carey, D. J. ;

Still, C. D. ;

Feldman, M. D. ;

Small, A. ;

Damrauer, S. M. ;

Rader, D. J. ;

Zambrowicz, B. ;

Olson, W. ;

Murphy, A. J. ;

Borecki, I. B. ;

Shuldiner, A. R. ;

Reid, J. G. ;

Overton, J. D. ;

Yancopoulos, G. D. ;

Hobbs, H. H. ;

Cohen, J. C. ;

Gottesman, O. ;

Teslovich, T. M. ;

Baras, A. ;

Mirshahi, T. ;

Gromada, J. ;

Dewey, F. E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (12) :1096-1106

[3] The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications [J].

Alisi, Anna ;

Carpino, Guido ;

Oliveira, Felipe L. ;

Panera, Nadia ;

Nobili, Valerio ;

Gaudio, Eugenio .

MEDIATORS OF INFLAMMATION, 2017, 2017

[4]

Ampuero J, 2015, REV ESP ENFERM DIG, V107, P10

[5] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[6] Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease [J].

Arab, Juan Pablo ;

Arrese, Marco ;

Trauner, Michael .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13, 2018, 13 :321-350

[7] Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study [J].

Armstrong, Matthew James ;

Gaunt, Piers ;

Aithal, Guruprasad P. ;

Barton, Darren ;

Hull, Diana ;

Parker, Richard ;

Hazlehurst, Jonathan M. ;

Guo, Kathy ;

Abouda, George ;

Aldersley, Mark A. ;

Stocken, Deborah ;

Gough, Stephen C. ;

Tomlinson, Jeremy W. ;

Brown, Rachel M. ;

Huebscher, Stefan G. ;

Newsome, Philip N. .

LANCET, 2016, 387 (10019) :679-690

[8] Bariatric Surgery and Non-Alcoholic Fatty Liver Disease: a Systematic Review of Liver Biochemistry and Histology [J].

Bower, Guy ;

Toma, Tania ;

Harling, Leanne ;

Jiao, Long R. ;

Efthimiou, Evangelos ;

Darzi, Ara ;

Athanasiou, Thanos ;

Ashrafian, Hutan .

OBESITY SURGERY, 2015, 25 (12) :2280-2289

[9] Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease [J].

Brouwers, Martijn C. G. J. ;

Simons, Nynke ;

Stehouwer, Coen D. A. ;

Koek, Ger H. ;

Schaper, Nicolaas C. ;

Isaacs, Aaron .

HEPATOLOGY COMMUNICATIONS, 2019, 3 (04) :587-596

[10] Statins and hepatic steatosis: Perspectives from the Dallas Heart Study [J].

Browning, Jeffrey D. .

HEPATOLOGY, 2006, 44 (02) :466-471

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