Detailed identification of plasma proteins adsorbed on copolymer nanoparticles

被引：676

作者：

Cedervall, Tommy

Lynch, Iseult ^{[1
]}

Foy, Martina

Berggard, Tord

Donnelly, Seamas C.

Cagney, Gerard

Linse, Sara

Dawson, Kenneth A.

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, Dublin 4, Ireland

[2] Univ Coll Dublin, UCD Conway Inst, Dublin 4, Ireland

[3] Lund Univ, Dept Protein Technol, S-22184 Lund, Sweden

[4] Lund Univ, Ctr Chem, S-22100 Lund, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 30期

关键词：

adsorption; lipoproteins; nanoparticles; proteomics; toxicology;

D O I：

10.1002/anie.200700465

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Blood relations: Nanoparticles that enter the bloodstream become coated with proteins. Four apolipoproteins are consistently recovered on model copolymer nanoparticles by using a centrifugation procedure (see electropherogram); their interaction with the nanoparticles is stronger than that of other plasma proteins with higher abundance. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：5754 / 5756

页数：3

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