Detailed identification of plasma proteins adsorbed on copolymer nanoparticles

被引：669
作者：
Cedervall, Tommy
Lynch, Iseult [1 ]
Foy, Martina
Berggard, Tord
Donnelly, Seamas C.
Cagney, Gerard
Linse, Sara
Dawson, Kenneth A.
机构：
[1] Univ Coll Dublin, Sch Chem & Chem Biol, Dublin 4, Ireland
[2] Univ Coll Dublin, UCD Conway Inst, Dublin 4, Ireland
[3] Lund Univ, Dept Protein Technol, S-22184 Lund, Sweden
[4] Lund Univ, Ctr Chem, S-22100 Lund, Sweden
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 30期
关键词：
adsorption; lipoproteins; nanoparticles; proteomics; toxicology;
D O I：
10.1002/anie.200700465
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Blood relations: Nanoparticles that enter the bloodstream become coated with proteins. Four apolipoproteins are consistently recovered on model copolymer nanoparticles by using a centrifugation procedure (see electropherogram); their interaction with the nanoparticles is stronger than that of other plasma proteins with higher abundance. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5754 / 5756
页数：3
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