Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation

被引：88
|
作者：
Yang, Chunxi [1 ,2 ,3 ]
Yuan, Guangyin [4 ]
Zhang, Jia [4 ]
Tang, Ze [2 ,3 ]
Zhang, Xiaoling [2 ,3 ]
Dai, Kerong [1 ,2 ,3 ,5 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Orthoped, Peoples Hosp 9, Shanghai 200011, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Osteopaed Cellular & Mol Biol, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Natl Engn Res Ctr Light Alloys Net Forming LAF, Shanghai 200240, Peoples R China
[5] Minist Educ, Engn Res Ctr Digital Med, Shanghai 200030, Peoples R China
来源：
BIOMEDICAL MATERIALS | 2010年 / 5卷 / 04期
关键词：
IN-VIVO EVALUATION; OSTEOBLASTIC DIFFERENTIATION; CORROSION; VITRO; PROLIFERATION; REGENERATION;
D O I：
10.1088/1748-6041/5/4/045005
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, adult human bone marrow-derived stromal cells (hBMSCs) were cultured in extracts of magnesium (Mg) and the Mg alloys AZ91D and NZ30K for 12 days. We studied the indirect effects of Mg alloys on hBMSC viability. Alkaline phosphatase activity and the expression of osteogenic differentiation marker genes were used to evaluate the effects of the Mg alloys on the osteogenic differentiation of hBMSCs. The results indicate that <= 10 mM concentration of Mg in the extracts did not inhibit the viability and osteogenic differentiation of hBMSCs. However, the results suggest that the high pH of the extracts, which is a result of the rapid corrosion of Mg and the Mg alloys, is unfavorable to the viability and osteogenic differentiation of hBMSCs.
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页数：9
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