hepatitis C virus infection;
hepatocellular carcinoma;
hepatitis B virus co-infection;
anti-core antibody;
viral DNA integration;
D O I:
暂无
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). We investigated the role of HBV coinfection in ongoing HCV-related liver diseases in HCV-infected patients. We found a high prevalence of anti-HBc in anti-HCV-positive/HBsAg-negative HCC patients and also found a close correlation between anti-HBc positivity and integration of HBV DNA into HCC DNA of anti-HCV-positive/HBsAg-negative patients. The present data suggest that integrated HBV DNA may play an important role in the development of HCC in the anti-HCV-positive/HBsAg-negative patients carrying the anti-HBc antibody.
机构:Meir Med Ctr, Dept Labs, Mol Biol Lab, Gastrointestinal Unit, IL-44281 Kefar Sava, Israel
Zemer, R.
Cohen, Y. Kitay
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机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelMeir Med Ctr, Dept Labs, Mol Biol Lab, Gastrointestinal Unit, IL-44281 Kefar Sava, Israel
Cohen, Y. Kitay
Naftaly, T.
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Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelMeir Med Ctr, Dept Labs, Mol Biol Lab, Gastrointestinal Unit, IL-44281 Kefar Sava, Israel
Naftaly, T.
Klein, A.
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Meir Med Ctr, Dept Labs, Mol Biol Lab, Gastrointestinal Unit, IL-44281 Kefar Sava, IsraelMeir Med Ctr, Dept Labs, Mol Biol Lab, Gastrointestinal Unit, IL-44281 Kefar Sava, Israel
机构:
Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, England
Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Li, Ka-Kit
Trivedi, Palak J.
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Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, England
Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Trivedi, Palak J.
Von Heimendahl, Sophie
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Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Von Heimendahl, Sophie
Bruns, Tony
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h-index: 0
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Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Bruns, Tony
Ward, Steve T.
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Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Ward, Steve T.
Oo, Ye
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h-index: 0
机构:
Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, England
Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Oo, Ye
Mutimer, David
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h-index: 0
机构:
Univ Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
Univ Birmingham, Liver Res Ctr, Birmingham, W Midlands, England
Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, EnglandUniv Birmingham, NIHR Biomed Res Unit, Birmingham, W Midlands, England
机构:
Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Catholic Univ, Liver Res Ctr, Seoul, South KoreaCatholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Kim, Jin Seoub
Kim, Hye Seon
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机构:
Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Catholic Univ, Liver Res Ctr, Seoul, South KoreaCatholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Kim, Hye Seon
Tak, Kwon Yong
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h-index: 0
机构:
Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Catholic Univ, Liver Res Ctr, Seoul, South KoreaCatholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Tak, Kwon Yong
Nam, Heechul
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h-index: 0
机构:
Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Catholic Univ, Liver Res Ctr, Seoul, South KoreaCatholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
Nam, Heechul
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Sung, Pil Soo
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Bae, Si Hyun
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Choi, Jong Young
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Yoon, Seung Kew
Roberts, Lewis R.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Div Gastroenterol & Hepatol, Rochester, MN USACatholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea