Adenosine and 2′-Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators

被引：37

作者：

Bednarska, Katarzyna ^{[2
]}

Olejniczak, Agnieszka B. ^{[1
]}

Wojtczak, Blazej A. ^{[1
]}

Sulowska, Zofia ^{[2
]}

Lesnikowski, Zbigniew J. ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Med Biol, Lab Mol Virol & Biol Chem, PL-93232 Lodz, Poland

[2] Polish Acad Sci, Inst Med Biol, Expt Immunol Lab, PL-93232 Lodz, Poland

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 05期

关键词：

aggregation; blood platelets; boranes; conjugates; nucleosides; MEDICINAL CHEMISTRY; RECEPTOR AGONISTS; DERIVATIVES; DESIGN; OPPORTUNITIES; ANTAGONISTS; MYOCARDIUM; ACTIVATION; CARBORANE; IMMUNITY;

D O I：

10.1002/cmdc.201000075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel types of adenosine and 2'-deoxyadenosine derivatives containing boron clusters at positions C2', N6, or C8 were synthesized. The effect of these modified compounds on platelet function was studied. Modification of adenosine at the C2' position with a para-carborane cluster (C2B10H11) results in efficient inhibition of platelet function, including aggregation, protein secretion, and P-selectin expression induced by thrombin or ADP. These preliminary findings and the new chemistry proposed form the basis for the development of a new class of adenosine analogues that modulate human blood platelet activities.

引用

页码：749 / 756

页数：8

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