Efficient tetrahydropyranylation of phenols and alcohols catalyzed by supported Mo and W keggin heteropolyacids

被引：19

作者：

Romanelli, GP

Vázquez, PG

Pizzio, LR

Cáceres, CV

Blanco, MN

Autino, JC

机构：

[1] Natl Univ La Plata, Fac Ciencias Exactas, Dept Quim, Lab Estudio Compuestos Organ, RA-1900 La Plata, Argentina

[2] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Quim, CONICET Ctr Invest Proc CINDECA, La Plata, Argentina

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 08期

关键词：

protecting group; tetrahydropyranyl; heteropolyacids; Keggin catalyst; alcohols; phenols;

D O I：

10.1081/SCC-120018695

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protection of phenols as tetrahydropyranyl acetals is studied using supported Keggin heteropolyacids as catalysts, specifically molybdophosphoric or tungstophosphoric acids supported on silica. Phenol tetrahydropyranyl acetals are obtained in short times at room temperature with excellent yields. Protection of alcohols is also performed under mild conditions using both supported heteropolyacids, with yields ranging between good and quantitative. The reactions are clean and their workup is very simple. The use of these solid catalysts allows replacing the usual soluble inorganic acids, contributing to waste reduction.

引用

页码：1359 / 1365

页数：7

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