机构:
BioMed Cent, BMC Biol, 236 Grays Inn Rd, London WC1X 8HB, EnglandBioMed Cent, BMC Biol, 236 Grays Inn Rd, London WC1X 8HB, England
Bell, Graham
[1
]
机构:
[1] BioMed Cent, BMC Biol, 236 Grays Inn Rd, London WC1X 8HB, England
来源:
BMC BIOLOGY
|
2016年
/
14卷
关键词:
Protein Expression;
Mouse Model;
Repeat Measurement;
Knockout Mouse;
Mutant Mouse;
D O I:
10.1186/s12915-016-0254-5
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mouse compared with the control. The results are reported as statistically significant, with impressive 'n' values in each condition: the authors say that n = 7 in each case. They confidently conclude that the level of each of the three proteins is increased in the knockout mutant.