A short enantioselective synthesis of guggultetrol, a naturally occurring lipid

被引：13
|
作者：
George, Shyla [1 ]
Suryavanshi, Gurunath [1 ]
Sudalai, Arumugam [1 ]
机构：
[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 05期
关键词：
ASYMMETRIC ALPHA-AMINOOXYLATION; AYURVEDIC CRUDE DRUGS; COMMIPHORA-MUKUL; DIHYDROXYLATION; (-)-CYTOXAZONE; EPOXIDATION; CHEMISTRY; ALCOHOLS; ROUTE; AGENT;
D O I：
10.1016/j.tetasy.2010.02.019
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An enantioselective synthesis of the naturally occurring lipid, guggultetrol, is described with an overall yield of 24% starting from commercially available 1-pentadecanol in ten linear steps. The key chiral-inducing steps include a Sharpless asymmetric epoxidation of allylic alcohol and a dihydroxylation of an alpha,beta-unsaturated ester. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：558 / 561
页数：4
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