A short enantioselective synthesis of guggultetrol, a naturally occurring lipid

被引：13

作者：

George, Shyla ^{[1
]}

Suryavanshi, Gurunath ^{[1
]}

Sudalai, Arumugam ^{[1
]}

机构：

[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 05期

关键词：

ASYMMETRIC ALPHA-AMINOOXYLATION; AYURVEDIC CRUDE DRUGS; COMMIPHORA-MUKUL; DIHYDROXYLATION; (-)-CYTOXAZONE; EPOXIDATION; CHEMISTRY; ALCOHOLS; ROUTE; AGENT;

D O I：

10.1016/j.tetasy.2010.02.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enantioselective synthesis of the naturally occurring lipid, guggultetrol, is described with an overall yield of 24% starting from commercially available 1-pentadecanol in ten linear steps. The key chiral-inducing steps include a Sharpless asymmetric epoxidation of allylic alcohol and a dihydroxylation of an alpha,beta-unsaturated ester. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：558 / 561

页数：4

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