Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds

被引：1
作者：
Pan, Junzhu [1 ]
Wang, Qianqian [1 ]
He, Gu [1 ,2 ]
Ouyang, Liang [1 ]
Guo, Li [1 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Minist Educ,Dept Med Chem, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Analgesic; Calcium antagonist; Synthesis; Hot-plate test; L-amino acid; CALCIUM-CHANNEL BLOCKERS; NEUROPATHIC PAIN; CA2+ CHANNEL; DERIVATIVES; EFFICACY;
D O I：
10.2174/157018010791163497
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by (1)H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.
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页码：359 / 364
页数：6
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