Maghemite-containing PLGA-PEG-based polymeric nanoparticles for siRNA delivery: toxicity and silencing evaluation

被引：2

作者：

Lellouche, Emmanuel ^{[1
,4
]}

Locatelli, Erica ^{[2
]}

Israel, Liron Limor ^{[3
,4
]}

Naddaka, Maria ^{[5
]}

Kurlander, Ella ^{[1
,4
]}

Michaeli, Shulamit ^{[1
,4
]}

Lellouche, Jean-Paul ^{[3
,4
]}

Franchini, Mauro Comes ^{[2
]}

机构：

[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel

[2] Univ Bologna, Dept Ind Chem Toso Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy

[3] Bar Ilan Univ, Fac Exact Sci, Dept Chem, Ramat Gan, Israel

[4] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, Ramat Gan, Israel

[5] Univ Liverpool, Stephenson Inst Renewable Energy, Peach St, Liverpool L69 7ZF, Merseyside, England

来源：

RSC ADVANCES | 2017年 / 7卷 / 43期

关键词：

TIMED-RELEASE; DESIGN; NANOCOMPOSITE;

D O I：

10.1039/c7ra00517b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gene therapy based on small interfering RNA (siRNA) has emerged as an exciting new therapeutic approach. In this work, incorporation of PEI into poly(D, L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-b-PEG) particles has been shown to be quite effective in the development of corresponding gene delivery systems, and encapsulation of magnetic nanoparticles as an MRI contrast agent, resulted in unique theranostic nanoparticles.

引用

页码：26912 / 26920

页数：9

共 28 条

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