Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

被引：33
作者：
Vaeggemose, Michael [1 ,2 ]
Schulte, Rolf F. [3 ]
Laustsen, Christoffer [2 ]
机构：
[1] GE Healthcare, DK-2605 Brondby, Denmark
[2] Aarhus Univ, MR Res Ctr, Dept Clin Med, DK-8000 Aarhus, Denmark
[3] GE Healthcare, D-80807 Munich, Germany
来源：
METABOLITES | 2021年 / 11卷 / 04期
关键词：
hyperpolarized carbon-13 MRI; review; clinical application; MAGNETIC-RESONANCE-SPECTROSCOPY; PARAHYDROGEN INDUCED POLARIZATION; IN-VIVO; SPECTRAL LOCALIZATION; METABOLIC MR; PYRUVATE; NMR; LIVER; THERAPY; QUANTITATION;
D O I：
10.3390/metabo11040219
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications. The status and upcoming challenges of translating HP carbon-13 into clinical application are reviewed, along with the complexity, technical advancements, and future directions. The road to clinical application is discussed regarding clinical needs and technological advancements, highlighting the most recent successes of metabolic imaging with hyperpolarized carbon-13 MRI. Given the current state of hyperpolarized carbon-13 MRI, the conclusion of this review is that the workflow for hyperpolarized carbon-13 MRI is the limiting factor.
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收藏
页数：22
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