Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

被引：33
作者：
Vaeggemose, Michael [1 ,2 ]
Schulte, Rolf F. [3 ]
Laustsen, Christoffer [2 ]
机构：
[1] GE Healthcare, DK-2605 Brondby, Denmark
[2] Aarhus Univ, MR Res Ctr, Dept Clin Med, DK-8000 Aarhus, Denmark
[3] GE Healthcare, D-80807 Munich, Germany
来源：
METABOLITES | 2021年 / 11卷 / 04期
关键词：
hyperpolarized carbon-13 MRI; review; clinical application; MAGNETIC-RESONANCE-SPECTROSCOPY; PARAHYDROGEN INDUCED POLARIZATION; IN-VIVO; SPECTRAL LOCALIZATION; METABOLIC MR; PYRUVATE; NMR; LIVER; THERAPY; QUANTITATION;
D O I：
10.3390/metabo11040219
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications. The status and upcoming challenges of translating HP carbon-13 into clinical application are reviewed, along with the complexity, technical advancements, and future directions. The road to clinical application is discussed regarding clinical needs and technological advancements, highlighting the most recent successes of metabolic imaging with hyperpolarized carbon-13 MRI. Given the current state of hyperpolarized carbon-13 MRI, the conclusion of this review is that the workflow for hyperpolarized carbon-13 MRI is the limiting factor.
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收藏
页数：22
相关论文
共 158 条
[1]   Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer [J].
Aggarwal, Rahul ;
Vigneron, Daniel B. ;
Kurhanewicz, John .
EUROPEAN UROLOGY, 2017, 72 (06) :1028-1029
[2]   Hyperpolarized MR - What's up Doc? [J].
Ardenkjaer-Larsen, Jan H. .
JOURNAL OF MAGNETIC RESONANCE, 2019, 306 :124-127
[3]   Dynamic Nuclear Polarization Polarizer for Sterile Use Intent [J].
Ardenkjaer-Larsen, Jan H. ;
Leach, Andrew M. ;
Clarke, Neil ;
Urbahn, John ;
Anderson, Denise ;
Skloss, Timothy W. .
NMR IN BIOMEDICINE, 2011, 24 (08) :927-932
[4]   Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T [J].
Ardenkjaer-Larsen, Jan Henrik ;
Bowen, Sean ;
Petersen, Jan Raagaard ;
Rybalko, Oleksandr ;
Vinding, Mads Sloth ;
Ullisch, Marcus ;
Nielsen, Niels Chr. .
MAGNETIC RESONANCE IN MEDICINE, 2019, 81 (03) :2184-2194
[5]   On the present and future of dissolution-DNP [J].
Ardenkjaer-Larsen, Jan Henrik .
JOURNAL OF MAGNETIC RESONANCE, 2016, 264 :3-12
[6]   Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR [J].
Ardenkjaer-Larsen, JH ;
Fridlund, B ;
Gram, A ;
Hansson, G ;
Hansson, L ;
Lerche, MH ;
Servin, R ;
Thaning, M ;
Golman, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10158-10163
[7]   Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging [J].
Arunachalam, Arjun ;
Whitt, David ;
Fish, Kenneth ;
Giaquinto, Randy ;
Piel, Joseph ;
Watkins, Ronald ;
Hancu, Ileana .
NMR IN BIOMEDICINE, 2009, 22 (08) :867-873
[8]   Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers [J].
Autry, A. W. ;
Park, I. ;
Kline, C. ;
Chen, H. -Y. ;
Gordon, J. W. ;
Raber, S. ;
Hoffman, C. ;
Kim, Y. ;
Okamoto, K. ;
Vigneron, D. B. ;
Lupo, J. M. ;
Prados, M. ;
Li, Y. ;
Xu, D. ;
Mueller, S. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2021, 42 (01) :178-184
[9]   Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma [J].
Autry, Adam W. ;
Gordon, Jeremy W. ;
Chen, Hsin-Yu ;
LaFontaine, Marisa ;
Bok, Robert ;
Van Criekinge, Mark ;
Slater, James B. ;
Carvajal, Lucas ;
Villanueva-Meyer, Javier E. ;
Chang, Susan M. ;
Clarke, Jennifer L. ;
Lupo, Janine M. ;
Xu, Duan ;
Larson, Peder E. Z. ;
Vigneron, Daniel B. ;
Li, Yan .
NEUROIMAGE-CLINICAL, 2020, 27
[10]   Hyperpolarized 13C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model [J].
Baligand, Celine ;
Qin, Hecong ;
True-Yasaki, Aisha ;
Gordon, Jeremy W. ;
von Morze, Cornelius ;
Delos Santos, Justin ;
Wilson, David M. ;
Raffai, Robert ;
Cowley, Patrick M. ;
Baker, Anthony J. ;
Kurhanewicz, John ;
Lovett, David H. ;
Wang, Zhen Jane .
NMR IN BIOMEDICINE, 2017, 30 (10)
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