Mitotane (o,p′-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma

被引：11
作者：
Bennett, PF
Norman, EJ
机构：
[1] Compan Anim Referral Serv, Mt Waverley, Vic 3149, Australia
[2] Univ Glasgow, Sch Vet, Div Small Anim Clin Studies, Glasgow G61 1QH, Lanark, Scotland
来源：
AUSTRALIAN VETERINARY JOURNAL | 1998年 / 76卷 / 02期
关键词：
pituitary-dependent hyperadrenocorticism; phaeochromocytoma; mitotane; dog;
D O I：
10.1111/j.1751-0813.1998.tb14536.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary-dependent hyperadrenocorticism. A low-dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/kg/d without complete resolution of signs. The dog collapsed with signs consistent with liver disease and was euthanased. Necropsy revealed a phaeochromocytoma of the left adrenal medulla with extensive metastases to the liver. A chromophobe adenoma of the pars intermedia of the pituitary was found.
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页码：101 / 103
页数：3
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