Protective role of nimbolide against chemotherapeutic drug hydroxyurea induced genetic and oxidative damage in an animal model

被引：20

作者：

Ahmad, Md Fahim ^{[1
]}

Ansari, Mohd Owais ^{[1
]}

Jameel, Sana ^{[1
]}

Wani, Ab Latif ^{[1
]}

Parveen, Nuzhat ^{[1
]}

Siddique, Hifzur R. ^{[2
]}

Shadab, G. G. H. A. ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Dept Zool, Sect Genet, Cytogenet & Mol Toxicol Lab, Aligarh 202002, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Dept Zool, Sect Genet, Mol Canc Genet & Translat Res Lab, Aligarh 202002, Uttar Pradesh, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2018年 / 60卷

关键词：

Nimbolide; Hydroxyurea; Chromosomal aberrations; Micronucleus test; Oxidative damage; SICKLE-CELL-DISEASE; POLYCYTHEMIA-VERA; DNA-DAMAGE; THERAPY; STRESS; TOXICITY; ANEMIA; RATS; ERYTHROCYTES; GENOTOXICITY;

D O I：

10.1016/j.etap.2018.04.006

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nimbolide is known to be an antioxidant found in neem plant. Hydroxyurea is a medication frequently used in sickle-cell disease, different cancers and HIV infection. The present study aimed to evaluate the adverse effect of HU and possible amelioration by nimbolide in Wistar rats. To test our hypothesis, we performed genotoxicity tests, biochemical assays, and histopathological studies. We observed that HU caused higher levels of genotoxicity in the treated animals. The observed genetic and oxidative damage might be due to the presence of reactive species as HU increased the level of the malondialdehyde-a biomarker of oxidative damage. Interestingly, co-treatment of animals with HU and nimbolide showed a lower level of damage. We conclude that nimbolide significantly protects the cells from the adverse effect of HU and could be considered as a potential adjuvant for the patients under HU therapy.

引用

页码：91 / 99

页数：9

共 46 条

[21] Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease [J].