Novel polymorphisms in the 5′ region of the LEP gene -: Association with leptin levels and response to low-calorie diet in human obesity

被引:141
作者
Mammès, O
Betoulle, D
Aubert, R
Giraud, V
Tuzet, S
Petiet, A
Colas-Linhart, N
Fumeron, F
机构
[1] Fac Med Xavier Bichat, Lab Nutr Humaine, F-75870 Paris 18, France
[2] Fac Med Xavier Bichat, Biophys Lab, F-75870 Paris, France
关键词
D O I
10.2337/diabetes.47.3.487
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:487 / 489
页数:3
相关论文
共 11 条
[1]  
BOUCHARD C, 1993, ANNU REV NUTR, V13, P337, DOI 10.1146/annurev.nu.13.070193.002005
[2]   The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks [J].
Campfield, LA ;
Smith, FJ ;
Burn, P .
HORMONE AND METABOLIC RESEARCH, 1996, 28 (12) :619-632
[3]   Indication for linkage of the human OB gene region with extreme obesity [J].
Clement, K ;
Garner, C ;
Hager, J ;
Philippi, A ;
LeDuc, C ;
Carey, A ;
Harris, TJR ;
Jury, C ;
Cardon, LR ;
Basdevant, A ;
Demenais, F ;
GuyGrand, B ;
North, M ;
Froguel, P .
DIABETES, 1996, 45 (05) :687-690
[4]   Mutation screening and identification of a sequence variation in the human OB gene coding region [J].
Considine, RV ;
Considine, EL ;
Williams, CJ ;
Nyce, MR ;
Zhang, P ;
Opentanova, I ;
Ohannesian, JP ;
Kolaczynski, JW ;
Bauer, TL ;
Moore, JH ;
Caro, JF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 220 (03) :735-739
[5]   Identification of two novel missense mutations in the human OB gene [J].
Echwald, SM ;
Rasmussen, SB ;
Sorensen, TIA ;
Andersen, T ;
TybjaergHansen, A ;
Clausen, JO ;
Hansen, L ;
Hansen, T ;
Pedersen, O .
INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (04) :321-326
[6]  
Gong DW, 1996, J BIOL CHEM, V271, P3971
[7]   Absence of mutations in the human OB gene in obese diabetic subjects [J].
Maffei, M ;
Stoffel, M ;
Barone, M ;
Moon, B ;
Dammerman, M ;
Ravussin, E ;
Bogardus, C ;
Ludwig, DS ;
Flier, JS ;
Talley, M ;
Auerbach, S ;
Friedman, JM .
DIABETES, 1996, 45 (05) :679-682
[8]   Congenital leptin deficiency is associated with severe early-onset obesity in humans [J].
Montague, CT ;
Farooqi, IS ;
Whitehead, JP ;
Soos, MA ;
Rau, H ;
Wareham, NJ ;
Sewter, CP ;
Digby, JE ;
Mohammed, SN ;
Hurst, JA ;
Cheetham, CH ;
Earley, AR ;
Barnett, AH ;
Prins, JB ;
ORahilly, S .
NATURE, 1997, 387 (6636) :903-908
[9]   Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects [J].
Oksanen, L ;
Kainulainen, K ;
Heiman, M ;
Mustajoki, P ;
KauppinenMakelin, R ;
Kontula, K .
INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (06) :489-494
[10]   Extreme obesity may be linked to markers flanking the human OB gene [J].
Reed, DR ;
Ding, Y ;
Xu, WZ ;
Cather, C ;
Green, ED ;
Price, RA .
DIABETES, 1996, 45 (05) :691-694