Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

被引：228

作者：

Mathy, Nicholas W. ^{[1
]}

Chen, Xian-Ming ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, 2500 Calif Plaza, Omaha, NE 68178 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 30期

基金：

美国国家卫生研究院;

关键词：

chromatin remodeling; epigenetics; inflammation; long noncoding RNA (long ncRNA; lncRNA); NF-B; toll-like receptor (TLR); transcription regulation; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; GENE-EXPRESSION; REMODELING COMPLEXES; INTERFERON-GAMMA; KAWASAKI-DISEASE; IMMUNE-RESPONSE; CELIAC-DISEASE; CUTTING EDGE; ACTIVATION;

D O I：

10.1074/jbc.R116.760884

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. lncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and time-dependent fashion. Here, we will review recent literature regarding the role of lncRNAs in transcriptional control of inflammatory responses. Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies.

引用

页码：12375 / 12382

页数：8

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