Exip, a splicing variant of p38α, participates in interleukin-1 receptor proximal complex and downregulates NF-κB pathway

被引:16
|
作者
Yagasaki, Y
Sudo, T
Osada, H
机构
[1] RIKEN, Antibiot Lab, DRI, Wako, Saitama 3510198, Japan
[2] RIKEN, Bioarchitect Res Grp, DRI, Wako, Saitama 3510198, Japan
来源
FEBS LETTERS | 2004年 / 575卷 / 1-3期
关键词
D O I
10.1016/j.febslet.2004.08.050
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The members of the p38 mitogen-activated protein kinase, especially specific inhibitors such as SB203580 sensitive isoforms, have been shown to play important roles in immune responses as well as in many biological events. In the course of our study to understand how p38 can be responsible for numerous biological phenomena, we have recently identified Exip, an alternative splicing variant of p38alpha. Exip retains amino acids responsible for the sensitivity to SB203580. Exip may also be involved in the intracellular signal transduction pathway different from those of conventional p38s. Though Exip is less abundant, it may play a critical role under certain circumstances. Here we report that Exip, but not p38alpha, binds to Toll interacting protein which is involved in interleukin-1 (IL-1) signaling pathway as a component of the receptor proximal complex and impaired NF-kappaB activity. Moreover, Exip binds to another component of the complex, IL-1 associating kinase. Exogenous-expression of Exip resulted in downregulation of NF-kappaB activities both in HeLa and HEK293T cells. Together, these results demonstrate that Exip can be a new component of NF-kappaB pathway, and contribute to a comprehensive understanding of the signal transduction pathway in the inflammatory responses. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:136 / 140
页数:5
相关论文
共 50 条
  • [41] Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF-κB pathway
    Lin, L. -P.
    Niu, G. -H.
    Zhang, X. -Q.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (03) : 1296 - 1304
  • [42] Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts
    Park, Ii-Ho
    Um, Ji-Young
    Cho, Jung-Sun
    Lee, Seung Hoon
    Lee, Sang Hag
    Lee, Heung-Man
    ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2014, 6 (06) : 567 - 572
  • [43] Interleukin-1β-induced cyclooxygenase-2 expression is mediated through activation of p42/44 and p38 MAPKS, and NF-κB pathways in canine tracheal smooth muscle cells
    Yang, CM
    Chien, CS
    Hsiao, LD
    Luo, SF
    Wang, CC
    CELLULAR SIGNALLING, 2002, 14 (11) : 899 - 911
  • [44] Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia
    Lu, Fan
    Gong, Han
    Lei, Houkang
    Li, Juan
    BIOENGINEERED, 2022, 13 (02) : 3019 - 3028
  • [45] Propofol alleviates intestinal ischemia/reperfusion injury in rats through p38 MAPK/NF-κB signaling pathway
    Li, L.
    Shu, F.
    Wang, X-Q
    Wang, F.
    Cai, L.
    Zhao, X.
    Lv, H-G
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (03) : 1574 - 1581
  • [46] Age-related activation of MKK/p38/NF-κB signaling pathway in lung: From mouse to human
    Ren, Xiaoxia
    Du, Huadong
    Li, Yan
    Yao, Xiujuan
    Huang, Junmin
    Li, Zongli
    Wang, Wei
    Li, Junfa
    Han, Song
    Wang, Chen
    Huang, Kewu
    EXPERIMENTAL GERONTOLOGY, 2014, 57 : 29 - 40
  • [47] Gastrodin ameliorates acute pancreatitis by modulating macrophage inflammation cascade via inhibition the p38/NF-κB pathway
    Jiang, Yalan
    Wu, Huilan
    Peng, Yongmiao
    He, Pingping
    Qian, Songwei
    Lin, Hongzhou
    Chen, Huihui
    Qian, Rengcheng
    Wang, Dexuan
    Chu, Maoping
    Ji, Weiping
    Guo, Xiaoling
    Shan, Xiaoou
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 129
  • [48] Involvement of the p38/MAPK -: NF-κB signal transduction pathway and COX2 in the pathobiology of meniscus degeneration
    Papachristou, D. J.
    Papadakou, E.
    Baltopoulos, P.
    Papavassiliou, A. G.
    MODERN PATHOLOGY, 2008, 21 : 16A - 17A
  • [49] Involvement of the p38/MAPK -: NF-κB signal transduction pathway and COX2 in the pathobiology of meniscus degeneration
    Papachristou, D. J.
    Papadakou, E.
    Baltopoulos, P.
    Papavossiliou, A. G.
    LABORATORY INVESTIGATION, 2008, 88 : 16A - 17A
  • [50] Phoenixin-14 inhibits the formation of cerebral aneurysms in rats by downregulating the p38/NF-κB signaling pathway
    Li, Qizheng
    Zeng, Lin
    Peng, Songyang
    Zhu, Mengting
    Zhang, Yaodan
    NEUROPEPTIDES, 2025, 110