Effects of angiotensin II skin wound healing receptor signaling during

被引：83

作者：

Takeda, H ^{[1
]}

Katagata, Y ^{[1
]}

Hozumi, Y ^{[1
]}

Kondo, S ^{[1
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Dermatol, Yamagata 9909585, Japan

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2004年 / 165卷 / 05期

关键词：

D O I：

10.1016/S0002-9440(10)63422-0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The tissue angiotensin (Ang) system, which acts independently of the circulating renin Ang system, is supposed to play an important role in tissue repair in the heart and kidney. In the skin, the role of the system for wound heating has remained to be ascertained. Our study demonstrated that oral administration of selective AngII type-1 receptor (AT(1)) blocker suppressed keratinocyte re-epithelization and angiogenesis during skin wound healing in rats. Immunoprecipitation and Western blot analysis indicated the existence of AT(1) and AngII type-2 receptor (AT(2)) in cultured keratinocytes and myofibroblasts. In a bromodeoxyuridine incorporation study, induction of AT(1) signaling enhanced the incorporation into keratinocytes and myofibroblasts. Wound healing migration assays revealed that induction of AT(1) signaling accelerated keratinocyte re-epithetization and myofibroblasts recovering. In these experiments, induction of AT(2) signaling acted vice versa. Taken together, our study suggests that skin wound healing is regulated by balance of opposing signals between AT(1) and AT(2).

引用

页码：1653 / 1662

页数：10

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