An allylic isoprenoid C-5 nucleophile for the synthesis of forskolin

被引：13

作者：

Behnke, D ^{[1
]}

Hamm, S ^{[1
]}

Hennig, L ^{[1
]}

Welzel, P ^{[1
]}

机构：

[1] UNIV LEIPZIG,INST ORGAN CHEM,D-04103 LEIPZIG,GERMANY

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01662-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

InCl3-mediated coupling of delta-alkoxy allylic stannane 9b with aldehydes has been shown to give the a-coupling products in high yield, probably via two S-E' processes. Most specifically, drimenal (rac-1) has been converted into labdane derivative 17 which is considered to be an important intermediate on the way to forskolin. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：7059 / 7062

页数：4

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