Catalytic asymmetric Pauson-Khand-type reactions of enynes with formaldehyde in aqueous media

被引：52

作者：

Fuji, K ^{[1
]}

Morimoto, T ^{[1
]}

Tsutsumi, K ^{[1
]}

Kakiuchi, K ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期

基金：

日本学术振兴会;

关键词：

Pauson-Khand; asymmetric catalysis; enynes; formaldehyde;

D O I：

10.1016/j.tetlet.2004.10.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of an aqueous, asymmetric, and CO gas-free Pauson-Khand-type reaction is described. Using formaldehyde as a commercially available substitute for carbon monoxide, combined use of a hydrophilic phosphine (TPPTS) and a hydrophobic, chiral phosphine (tolBINAP) enable the reaction to proceed smoothly in aqueous media, even in the absence of carbon monoxide, and stereoselectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9163 / 9166

页数：4

共 20 条

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