Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C-H Bond Activation

被引：23

作者：

Chen, Mu-Yi ^{[1
]}

Pannecoucke, Xavier ^{[1
]}

Jubault, Philippe ^{[1
]}

Besset, Tatiana ^{[1
]}

机构：

[1] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA UMR 6014, F-76000 Rouen, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 20期

基金：

欧洲研究理事会;

关键词：

NATURAL-PRODUCTS; FUNCTIONALIZATION; INHIBITORS; TRIFLUOROMETHYLTHIOLATION; HALOGENATION; DERIVATIVES; CONVERSION;

D O I：

10.1021/acs.joc.9b01872

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C-H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).

引用

页码：13194 / 13202

页数：9

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