The red cell distribution width as a prognostic indicator in upper aerodigestive tract (UADT) cancer: A systematic review and meta-analysis

被引：14
作者：
Tham, Tristan [1 ]
Bardash, Yonatan [1 ]
Teegala, Sushma [1 ]
Herman, Wendy Saori [2 ]
Costantino, Peter David [1 ]
机构：
[1] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Otolaryngol Head & Neck Surg, 130 East 77th St,10th Floor, New York, NY 10075 USA
[2] Donald & Barbara Zucker Sch Med Hofstra Northwell, New York, NY USA
来源：
AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2018年 / 39卷 / 04期
关键词：
RDW; Aerodigestive tract cancer; Cancer prognosis; Meta-analysis; LYMPHOCYTE RATIO; INFLAMMATION; PLATELET; PARAMETERS; RECURRENCE; THERAPY; HEAD;
D O I：
10.1016/j.amjoto.2018.04.013
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Purpose: The aim of this systematic review and meta-analysis was to investigate the relationship between the Red Cell Distribution Width (RDW) and prognosis in upper aerodigestive tract (UADT) cancer. Methods: PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS), disease specific survival (DSS), and recurrence free survival (RFS). Results: Our analysis included the results of 4200 patients in 8 cohorts. The pooled data demonstrated that an elevated RDW was associated with significantly poorer OS (HR: 1.44, 95% CI: 1.13-1.83), RFS (HR: 1.43, 95%CI: 1.13-1.82). The DSS result had high heterogeneity and 95% CI was not pooled. Conclusions: An elevated RDW may be an indicator of poor prognosis in UADT cancers in certain populations. Further research is needed to confirm this effect.
引用
收藏
页码：453 / 458
页数：6
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