The red cell distribution width as a prognostic indicator in upper aerodigestive tract (UADT) cancer: A systematic review and meta-analysis

被引：14

作者：

Tham, Tristan ^{[1
]}

Bardash, Yonatan ^{[1
]}

Teegala, Sushma ^{[1
]}

Herman, Wendy Saori ^{[2
]}

Costantino, Peter David ^{[1
]}

机构：

[1] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Otolaryngol Head & Neck Surg, 130 East 77th St,10th Floor, New York, NY 10075 USA

[2] Donald & Barbara Zucker Sch Med Hofstra Northwell, New York, NY USA

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2018年 / 39卷 / 04期

关键词：

RDW; Aerodigestive tract cancer; Cancer prognosis; Meta-analysis; LYMPHOCYTE RATIO; INFLAMMATION; PLATELET; PARAMETERS; RECURRENCE; THERAPY; HEAD;

D O I：

10.1016/j.amjoto.2018.04.013

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose: The aim of this systematic review and meta-analysis was to investigate the relationship between the Red Cell Distribution Width (RDW) and prognosis in upper aerodigestive tract (UADT) cancer. Methods: PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS), disease specific survival (DSS), and recurrence free survival (RFS). Results: Our analysis included the results of 4200 patients in 8 cohorts. The pooled data demonstrated that an elevated RDW was associated with significantly poorer OS (HR: 1.44, 95% CI: 1.13-1.83), RFS (HR: 1.43, 95%CI: 1.13-1.82). The DSS result had high heterogeneity and 95% CI was not pooled. Conclusions: An elevated RDW may be an indicator of poor prognosis in UADT cancers in certain populations. Further research is needed to confirm this effect.

引用

页码：453 / 458

页数：6

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