Total Synthesis of Polyrhacitides A and B by Use of an Iterative Strategy for the Stereoselective Synthesis of 1,3-Polyol Arrays

被引：40
作者：
Menz, Helge
Kirsch, Stefan F. [1 ]
机构：
[1] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 24期
关键词：
NONRIBOSOMAL PEPTIDE ANTIBIOTICS; CHINESE MEDICINAL ANTS; FORMAL TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; CRYPTOCARYA LATIFOLIA; CARBONYL ALLYLATION; DELTA-LACTONES; ALPHA-PYRONES; POLYKETIDE; SUBUNIT;
D O I：
10.1021/ol902135v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first total syntheses of polyrhacitides A and B, secondary metabolites from Chinese medicinal ants, were accomplished via an iterative approach to the 1,3-polyol motif. For the construction of all stereogenic centers, the catalytic asymmetric Overman esterification was utilized.
引用
收藏
页码：5634 / 5637
页数：4
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