Co(II) and Ni(II) Complexes of a Heterocyclic Ligand: Synthesis, Characterization, Docking and Biological Activity

被引：7

作者：

Jain, Pallavi ^{[1
]}

Vishvakarma, Vijay K. ^{[2
]}

Singh, Prashant ^{[2
]}

Chandra, Sulekh ^{[3
]}

Kumar, Dinesh ^{[4
]}

Misra, Namita ^{[4
]}

机构：

[1] SRM Inst Sci & Technol, Dept Chem, Delhi NCR Campus, Modinagar 201204, India

[2] Atma Ram Sanatan Dharma Coll, Dept Chem, New Delhi 110021, India

[3] Univ Delhi, Dept Chem, Zakir Husain Delhi Coll, JLN Marg, New Delhi 110002, India

[4] Silver Oak Univ, Dept Chem, Ahmeadabad 382481, Gujrat, India

来源：

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE | 2022年 / 46卷 / 03期

关键词：

AMFT ligand; Metal complexes; Analytical techniques; MEP; Molecular docking; Antibacterial; Antifungal activities; TRANSITION-METAL-COMPLEXES; RU(II) COMPLEXES; CU(II) COMPLEXES; THIOSEMICARBAZONES; MN(II); MECHANISM; HYDROGEN;

D O I：

10.1007/s40995-022-01312-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Six different Co(II) and Ni(II) complexes of a heterocyclic tridentate 2-acetyl-5-methylfuranthiosemicarbazone (AMFT) schiff's base ligand were reported. Metal complexes were synthesized via conventional condensation and refluxing technique and characterized by different analytical techniques i.e., elemental analysis, molar conductance, magnetic moments and spectral i.e., IR, UV-Vis, EPR techniques. AMFT coordinated with the metal ion through three different heteroatoms i.e., oxygen, nitrogen and sulphur. Octahedral geometry was suggested by the experimental studies and also supported by theoretical studies. Chemical hardness and global softness value suggested high chemical reactivity of Co(II) complex. The charge transfer in the complexes were studied by MEP analysis. Antibacterial and antifungal activities of all the complexes were evaluated. The complexes showed better inhibition action than the parent ligand. Molecular docking was also performed to check the inhibition at atomic level and the result validated the experimental result. Ni(II) complexes showed better inhibition in comparison with Co(II) complexes.

引用

页码：793 / 805

页数：13

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