Pseudotyped AAV vectors for constitutive and regulated gene expression in the eye

被引：43
作者：
Auricchio, A [1 ]
机构：
[1] TIGEM, I-80131 Naples, Italy
来源：
VISION RESEARCH | 2003年 / 43卷 / 08期
关键词：
D O I：
10.1016/S0042-6989(02)00676-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Since the first reports describing the injection of recombinant adeno-associated viral (AAV) vectors in the murine eye, the advancement of the field has been enormous resulting in the correction of several animal models of retinal diseases. The recent development of "pseudotyped" AAV vectors with transduction characteristics that best fit the correction of specific retinal disease phenotypes and of sophisticated systems for tight regulation of gene expression expands on the potentiality of this delivery system for the eye. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：913 / 918
页数：6
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共 41 条
  • [1] Gene therapy restores vision in a canine model of childhood blindness
    Acland, GM
    Aguirre, GD
    Ray, J
    Zhang, Q
    Aleman, TS
    Cideciyan, AV
    Pearce-Kelling, SE
    Anand, V
    Zeng, Y
    Maguire, AM
    Jacobson, SG
    Hauswirth, WW
    Bennett, J
    [J]. NATURE GENETICS, 2001, 28 (01) : 92 - 95
  • [2] Adeno-associated virus gene transfer to mouse retina
    Ali, RR
    Reichel, MB
    De Alwis, M
    Kanuga, N
    Kinnon, C
    Levinsky, RJ
    Hunt, DM
    Bhattacharya, SS
    Thrasher, AJ
    [J]. HUMAN GENE THERAPY, 1998, 9 (01) : 81 - 86
  • [3] Gene transfer into the mouse retina mediated by an adeno-associated viral vector
    Ali, RR
    Reichel, MB
    Thrasher, AJ
    Levinsky, RJ
    Kinnon, C
    Kanuga, N
    Hunt, DM
    Bhattacharya, SS
    [J]. HUMAN MOLECULAR GENETICS, 1996, 5 (05) : 591 - 594
  • [4] Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy
    Ali, RR
    Sarra, GM
    Stephens, C
    de Alwis, M
    Bainbridge, JWB
    Munro, PM
    Fauser, S
    Reichell, MB
    Kinnon, C
    Hunt, DM
    Bhattacharya, SS
    Thrasher, AJ
    [J]. NATURE GENETICS, 2000, 25 (03) : 306 - 310
  • [5] ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES
    ATCHISON, RW
    CASTO, BC
    HAMMON, WM
    [J]. SCIENCE, 1965, 149 (3685) : 754 - &
  • [6] Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye
    Auricchio, A
    Rivera, VM
    Clackson, T
    O'Connor, EE
    Maguire, AM
    Tolentino, MJ
    Bennett, J
    Wilson, JM
    [J]. MOLECULAR THERAPY, 2002, 6 (02) : 238 - 242
  • [7] Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model
    Auricchio, A
    Kobinger, G
    Anand, V
    Hildinger, M
    O'Connor, E
    Maguire, AM
    Wilson, JM
    Bennett, J
    [J]. HUMAN MOLECULAR GENETICS, 2001, 10 (26) : 3075 - 3081
  • [8] AURICCHIO A, IN PRESS MOL THERAPY
  • [9] Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1
    Bainbridge, JWB
    Mistry, A
    De Alwis, M
    Paleolog, E
    Baker, A
    Thrasher, AJ
    Ali, RR
    [J]. GENE THERAPY, 2002, 9 (05) : 320 - 326
  • [10] CHARACTERIZATION OF THE DNA OF A DEFECTIVE HUMAN PARVOVIRUS ISOLATED FROM A GENITAL SITE
    BANTELSCHAAL, U
    HAUSEN, HZ
    [J]. VIROLOGY, 1984, 134 (01) : 52 - 63
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