Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives

被引：20

作者：

Surkau, Georg ^{[1
]}

Boehm, Konrad J. ^{[2
]}

Mueller, Klaus ^{[1
]}

Prinz, Helge ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut & Med Chem, D-48149 Munster, Germany

[2] FLI, Leibniz Inst Age Res, D-07745 Jena, Germany

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 08期

关键词：

Anthraquinone oximes; Anthracenones; 10-Hydroxyimino-10H-anthracen-9-ones; Tubulin polymerization; Antiproliferative activity; ANTIMICROTUBULE AGENTS; COLCHICINE SITE; BIOLOGICAL EVALUATION; COMMON PHARMACOPHORE; CANCER; MECHANISM; CLEAVAGE; LIGANDS;

D O I：

10.1016/j.ejmech.2010.04.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of anthracenone-based oxime ethers and -esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context, anthracenone-based oxime ethers and -esters are considered to contribute to the development of novel antiproliferative drugs, based on tubulin interaction. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3354 / 3364

页数：11

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