Genetics of Severe Cutaneous Adverse Reactions

被引：13

作者：

Yang, Shang-Chen ^{[1
]}

Chen, Chun-Bing ^{[1
,2
,3
,4
,5
,6
,7
]}

Lin, Mao-Ying ^{[1
]}

Zhang, Zhi-Yang ^{[1
]}

Jia, Xiao-Yan ^{[8
]}

Huang, Ming ^{[8
]}

Zou, Ya-Fen ^{[8
]}

Chung, Wen-Hung ^{[1
,2
,3
,4
,5
,7
,9
,10
,11
]}

机构：

[1] Xiamen Chang Gung Hosp, Dept Dermatol, Xiamen Chang Gung Allergol Consortium, Xiamen, Peoples R China

[2] Chang Gung Mem Hosp, Drug Hypersensit Clin & Res Ctr, Dept Dermatol, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Canc Vaccine & Immune Cell Therapy Core Lab, Dept Med Res, Taoyuan, Taiwan

[4] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp, Whole Genome Res Core Lab Human Dis, Keelung, Taiwan

[6] Chang Gung Univ, Grad Inst Clin Med Sci, Taoyuan, Taiwan

[7] Chang Gung Mem Hosp, Immune Oncol Ctr Excellence, Linkou, Taiwan

[8] Xiamen Chang Gung Hosp, Dept Neurol, Xiamen, Peoples R China

[9] Tsinghua Univ, Beijing Tsinghua Chang Gung Hosp, Sch Clin Med, Dept Dermatol, Beijing, Peoples R China

[10] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Dermatol, Shanghai, Peoples R China

[11] Chang Gung Mem Hosp, Genom Med Core Lab, Linkou, Taiwan

来源：

FRONTIERS IN MEDICINE | 2021年 / 8卷

关键词：

genetic screen; Stevens-Johnson syndrome; toxic epidermal necrolysis; pharmacogenomic; severe cutaneous adverse drug reactions; STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; GENOME-WIDE ASSOCIATION; HLA-DEPENDENT HYPERSENSITIVITY; SEVERE OCULAR COMPLICATIONS; SYSTEMIC SYMPTOMS DRESS; CLASS-I GENES; HLA-B-ASTERISK-1502; ALLELE; DRUG-REACTIONS; COLD MEDICINE;

D O I：

10.3389/fmed.2021.652091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.

引用

页数：9

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