Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

被引：2616
作者：
Peinado, Hector [1 ]
Olmeda, David [1 ]
Cano, Amparo [1 ]
机构：
[1] Univ Autonoma Madrid, Fac Med, CSIC, Inst Invest Biomed,Dept Bioquim, E-28029 Madrid, Spain
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期
关键词：
D O I：
10.1038/nrc2131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
引用
收藏
页码：415 / 428
页数：14
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