Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

被引：2616
作者：
Peinado, Hector [1 ]
Olmeda, David [1 ]
Cano, Amparo [1 ]
机构：
[1] Univ Autonoma Madrid, Fac Med, CSIC, Inst Invest Biomed,Dept Bioquim, E-28029 Madrid, Spain
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期
关键词：
D O I：
10.1038/nrc2131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
引用
收藏
页码：415 / 428
页数：14
相关论文
共 173 条
  • [1] N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1
    Alexander, NR
    Tran, NL
    Rekapally, H
    Summers, CE
    Glackin, C
    Heimark, RL
    [J]. CANCER RESEARCH, 2006, 66 (07) : 3365 - 3369
  • [2] Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene
    Alpatov, R
    Munguba, GC
    Caton, P
    Joo, JH
    Shi, Y
    Shi, YJ
    Hunt, ME
    Sugrue, SP
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (23) : 10223 - 10235
  • [3] Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition
    Bachelder, RE
    Yoon, SO
    Franci, C
    de Herreros, AG
    Mercurio, AM
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 168 (01) : 29 - 33
  • [4] BALLEY CK, 2006, BIOCHEM BIOPH RES CO, V353, P661
  • [5] Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
    Barberà, MJ
    Puig, I
    Domínguez, D
    Julien-Grille, S
    Guaita-Esteruelas, S
    Peiró, S
    Baulida, J
    Francí, C
    Dedhar, S
    Larue, L
    de Herreros, AG
    [J]. ONCOGENE, 2004, 23 (44) : 7345 - 7354
  • [6] The Snail genes as inducers of cell movement and survival: implications in development and cancer
    Barrallo-Gimeno, A
    Nieto, MA
    [J]. DEVELOPMENT, 2005, 132 (14): : 3151 - 3161
  • [7] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    Batlle, E
    Sancho, E
    Franci, C
    Domínguez, D
    Monfar, M
    Baulida, J
    de Herreros, AG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (02) : 84 - 89
  • [8] Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts
    Bermejo-Rodríguez, C
    Pérez-Caro, M
    Pérez-Mancera, PA
    Sánchez-Beato, M
    Piris, MA
    Sánchez-García, I
    [J]. GENOMICS, 2006, 87 (01) : 113 - 118
  • [9] CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS
    BIRCHMEIER, W
    BEHRENS, J
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01): : 11 - 26
  • [10] Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    Blanco, MJ
    Moreno-Bueno, G
    Sarrio, D
    Locascio, A
    Cano, A
    Palacios, J
    Nieto, MA
    [J]. ONCOGENE, 2002, 21 (20) : 3241 - 3246
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