An FRET-ICT-based ratiometric fluorescent and colorimetric probe for pH monitoring in lysosomes and water

被引：41

作者：

Li, Zhang-Yi ^{[1
]}

Cui, Xiao-Ling ^{[2
]}

Xiao, Meng-Min ^{[1
]}

Miao, Jun-Ying ^{[2
]}

Zhao, Bao-Xiang ^{[1
]}

Lin, Zhao-Min ^{[3
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Qingdao 266237, Peoples R China

[3] Shandong Univ, Inst Med Sci, Hosp 2, Jinan 250033, Peoples R China

来源：

DYES AND PIGMENTS | 2021年 / 193卷 / 193期

基金：

中国国家自然科学基金;

关键词：

FRET; Cell image; Lysosomes-targeted; Water samples; Ratiometric fluorescent and colorimetric pH  probe; LIVING CELLS; WAVELENGTH; PLATFORM; SENSOR; BRAIN;

D O I：

10.1016/j.dyepig.2021.109481

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel FRET-ICT-based ratiometric fluorescent and colorimetric pH probe (BDMNP) was developed. BDMNP exhibited 96% energy transfer efficiency and good linear response in the pH ranges of 5.4-6.8 (pKa = 6.10) with high selectivity and sensitivity. BDMNP has been successfully applied to monitor lysosomal pH changes in living cells. Meanwhile, BDMNP can also be used to detect the subtle pH changes of a variety of environmental water samples.

引用

页数：9

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