Viral Impact on Long-term Kidney Graft Function

被引：42

作者：

Helantera, Ilkka ^{[2
,3
,4
]}

Egli, Adrian ^{[1
,6
]}

Koskinen, Petri ^{[3
,4
]}

Lautenschlager, Irmeli ^{[2
,4
,5
]}

Hirsch, Hans H. ^{[1
,7
]}

机构：

[1] Univ Basel, Inst Med Microbiol, Dept Biomed, CH-4003 Basel, Switzerland

[2] Helsinki Univ Hosp, Transplant Unit, Res Lab, Transplantat & Liver Surg Clin, FI-00029 Helsinki, Hus, Finland

[3] Helsinki Univ Hosp, Div Nephrol, Dept Med, FI-00029 Helsinki, Hus, Finland

[4] Univ Helsinki, FI-00029 Helsinki, Hus, Finland

[5] Helsinki Univ Hosp, Dept Virol, FI-00029 Helsinki, Hus, Finland

[6] Univ Basel Hosp, Dept Med, CH-4031 Basel, Switzerland

[7] Univ Basel Hosp, Dept Internal Med Infect Dis & Hosp Epidemiol, CH-4031 Basel, Switzerland

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 02期

关键词：

BK virus; JC virus; Cytomegalovirus; Adenovirus; Parvovirus; HHV6; Kidney transplantation; Pathogenesis; PARVOVIRUS B19 INFECTION; HUMAN HERPESVIRUS-6 INFECTION; POLYOMAVIRUS-ASSOCIATED NEPHROPATHY; T-CELL RESPONSES; RENAL-TRANSPLANT RECIPIENTS; NECROSIS-FACTOR-ALPHA; PERSISTENT CYTOMEGALOVIRUS-INFECTION; SOLID-ORGAN TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; IMMEDIATE EARLY GENES;

D O I：

10.1016/j.idc.2010.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute rejection episodes are an important risk factor for the functional deterioration of solid-organ transplants. With more intense immunosuppressive protocols, the rate of acute rejection episodes has significantly declined in the last decade, but long-term graft function and graft survival are challenged by increasing viral complications. In this article, recent data on the role of adenovirus, polyomavirus BK and JC, cytomegalovirus, human herpesvirus-6 and -7, and parvovirus B19 on the long-term outcome of kidney transplantation are reviewed. An update on the pathophysiology of smoldering viral replication, associated inflammatory damage, and the presumed indirect viral effects is provided, and the implications for diagnostic tests and antiviral intervention are discussed.

引用

页码：339 / +

页数：34

共 276 条

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