Synthesis of Quinoline-2,4-diones from Cyanoacetanilide Derivatives

被引：3
|
作者：
Zhong, Shuaishuai [1 ]
Huang, Peng [1 ]
Wang, Xingyue [1 ]
Lin, Mi [1 ]
Ge, Chunhua [1 ]
机构：
[1] Liaoning Univ, Coll Chem, Shenyang 110036, Liaoning, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 05期
关键词：
quinolinone; nitrile; methylation; cvclization; RADICAL ADDITION/CYCLIZATION CASCADE; HOESCH-TYPE CYCLIZATION; EFFICIENT SYNTHESIS; CONSTRUCTION; KETONES; ALKYNES; PHENOL;
D O I：
10.6023/cjoc201711011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Quinoline-2,4-dione unit is present in many natural products and synthetic compounds along with a broad range of bioactivities. Herein, a new approach to the synthesis of quinoline-2,4-diones is developed based on a methyl triflate (TfOMe)-promoted intramolecular Houben-Hoesch reaction of alpha,alpha-dialkyl substituted cyanoacetanilides. The broad substrate scope, simple operation and mild reaction conditions make this synthetic method very attractive.
引用
收藏
页码：1199 / 1206
页数：8
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