Synthesis of Quinoline-2,4-diones from Cyanoacetanilide Derivatives

被引：3

作者：

Zhong, Shuaishuai ^{[1
]}

Huang, Peng ^{[1
]}

Wang, Xingyue ^{[1
]}

Lin, Mi ^{[1
]}

Ge, Chunhua ^{[1
]}

机构：

[1] Liaoning Univ, Coll Chem, Shenyang 110036, Liaoning, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 05期

关键词：

quinolinone; nitrile; methylation; cvclization; RADICAL ADDITION/CYCLIZATION CASCADE; HOESCH-TYPE CYCLIZATION; EFFICIENT SYNTHESIS; CONSTRUCTION; KETONES; ALKYNES; PHENOL;

D O I：

10.6023/cjoc201711011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinoline-2,4-dione unit is present in many natural products and synthetic compounds along with a broad range of bioactivities. Herein, a new approach to the synthesis of quinoline-2,4-diones is developed based on a methyl triflate (TfOMe)-promoted intramolecular Houben-Hoesch reaction of alpha,alpha-dialkyl substituted cyanoacetanilides. The broad substrate scope, simple operation and mild reaction conditions make this synthetic method very attractive.

引用

页码：1199 / 1206

页数：8

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