Interactions of a Non-Thermal Atmospheric Pressure Plasma Effluent with PC-3 Prostate Cancer Cells

被引：52

作者：

Gibson, Andrew R. ^{[1
]}

McCarthy, Helen O. ^{[2
]}

Ali, Ahalm A. ^{[2
]}

O'Connell, Deborah ^{[3
]}

Graham, William G. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Math & Phys, Ctr Plasma Phys, Belfast BT7 1NN, Antrim, North Ireland

[2] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland

[3] Univ York, York Plasma Inst, York YO10 5DD, N Yorkshire, England

来源：

PLASMA PROCESSES AND POLYMERS | 2014年 / 11卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

apoptosis; cancer; nitric oxide; plasma jet; radicals; NITRIC-OXIDE; POLY(ADP-RIBOSE) POLYMERASE; GAS-PLASMA; IN-VITRO; APOPTOSIS; DEATH;

D O I：

10.1002/ppap.201400111

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The effect of a radio-frequency driven, microscale non thermal atmospheric pressure plasma jet operated in helium with vol. 0.3% molecular oxygen gas admixture, on PC-3 prostate cancer cells has been investigated. The viability of cells exposed to the plasma was found to decrease with increasing plasma exposure time, with apoptosis through caspase and PARP cleavage being observed. High concentrations of nitrite and nitrate were detected in growth media exposed to the plasma and were found to increase in a time dependent manner post exposure. This indicates a slow release of reactive nitrogen species into the growth media, which is likely to influence cellular response to plasma exposure.

引用

页码：1142 / 1149

页数：8

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